Universität zu Köln

Jarvers, Irina ORCID: 0000-0002-8414-2895, Kandsperger, Stephanie, Schleicher, Daniel, Ando, Ayaka, Resch, Franz, Koenig, Julian, Kaess, Michael ORCID: 0000-0003-0031-7764 and Brunner, Romuald (2022). The relationship between adolescents? externalizing and internalizing symptoms and brain development over a period of three years. NeuroImage-Clin., 36. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1582

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Abstract

Background: Adolescence is a crucial period for both brain maturation and the emergence of mental health disorders. Associations between brain morphology and internalizing/externalizing symptomatology have been identified in clinical or at-risk samples, but age-related developmental differences were rarely considered. The current study investigated the longitudinal relationship between internalizing/externalizing symptoms and brain development in the absence of psychiatric disorders during early and late adolescence.Methods: 98 healthy adolescents within two cohorts (younger: 9 years, older: 12 years) participated in annual assessments for three years; a clinical assessment measuring their externalizing and internalizing symptoms (SDQ) and an MRI assessment measuring their brain volume and white matter microstructure, including frac-tional anisotropy (FA), mean diffusivity (MD) and average path length.Results: Linear mixed effect models and cross-lagged panel models showed that larger subcortical gray matter volume predicted more externalizing symptoms in older adolescents whereas decreases of subcortical gray matter volume predicted more externalizing symptoms for younger adolescents. Additionally, longer average white matter path length predicted more externalizing symptoms for older adolescents, while decreases in ce-rebral white matter volume were predictive of more externalizing symptoms for younger adolescents. There were no predictive effects for internalizing symptoms, FA or MD.Conclusions: Delays in subcortical brain maturation, in both early and late adolescence, are associated with in-creases in externalizing behavior which indicates a higher risk for psychopathology and warrants further investigations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jarvers, Irina UNSPECIFIED orcid.org/0000-0002-8414-2895 UNSPECIFIED Kandsperger, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Schleicher, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Ando, Ayaka UNSPECIFIED UNSPECIFIED UNSPECIFIED Resch, Franz UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaess, Michael UNSPECIFIED orcid.org/0000-0003-0031-7764 UNSPECIFIED Brunner, Romuald UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680619
DOI:	10.1016/j.nicl.2022.103195
Journal or Publication Title:	NeuroImage-Clin.
Volume:	36
Date:	2022
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2213-1582
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIFFICULTIES QUESTIONNAIRE; CORTICAL THICKNESS; DSM-IV; VOLUME; METAANALYSIS; DISORDERS; CHILDHOOD; BEHAVIORS; STRENGTHS; CHILDREN Multiple languages Neuroimaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68061