Universität zu Köln

Pakela, Julia M., Knopf, Antje ORCID: 0000-0001-8212-571X, Dong, Lei, Rucinski, Antoni ORCID: 0000-0002-5815-4606 and Zou, Wei (2022). Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future. Front. Oncol., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2234-943X

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Abstract

The major aim of radiation therapy is to provide curative or palliative treatment to cancerous malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy utilizing carbon ions or protons is uniquely suited for this task due to its ability to achieve highly conformal dose distributions around the tumor volume. For these treatment modalities, uncertainties in the localization of patient anatomy due to inter- and intra-fractional motion present a heightened risk of undesired dose delivery. A diverse range of mitigation strategies have been developed and clinically implemented in various disease sites to monitor and correct for patient motion, but much work remains. This review provides an overview of current clinical practices for inter and intra-fractional motion management in charged particle therapy, including motion control, current imaging and motion tracking modalities, as well as treatment planning and delivery techniques. We also cover progress to date on emerging technologies including particle-based radiography imaging, novel treatment delivery methods such as tumor tracking and FLASH, and artificial intelligence and discuss their potential impact towards improving or increasing the challenge of motion mitigation in charged particle therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pakela, Julia M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knopf, Antje UNSPECIFIED orcid.org/0000-0001-8212-571X UNSPECIFIED Dong, Lei UNSPECIFIED UNSPECIFIED UNSPECIFIED Rucinski, Antoni UNSPECIFIED orcid.org/0000-0002-5815-4606 UNSPECIFIED Zou, Wei UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680645
DOI:	10.3389/fonc.2022.806153
Journal or Publication Title:	Front. Oncol.
Volume:	12
Date:	2022
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2234-943X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MODULATED PROTON THERAPY; TIME TUMOR-TRACKING; TREATMENT PLANNING WORKSHOP; BODY RADIATION-THERAPY; RESPIRATORY MOTION; LUNG-CANCER; DOSE CALCULATION; BEAM THERAPY; RANGE UNCERTAINTIES; IMAGE REGISTRATION Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68064