Universität zu Köln

Rink-Notzon, Svenja, Reuscher, Jannika, Nohroudi, Klaus, Manthou, Marilena, Gordon, Tessa and Angelov, Doychin N. N. (2022). Trigeminal Sensory Supply Is Essential for Motor Recovery after Facial Nerve Injury. Int. J. Mol. Sci., 23 (23). BASEL: MDPI. ISSN 1422-0067

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Abstract

Recovery of mimic function after facial nerve transection is poor. The successful regrowth of regenerating motor nerve fibers to reinnervate their targets is compromised by (i) poor axonal navigation and excessive collateral branching, (ii) abnormal exchange of nerve impulses between adjacent regrowing axons, namely axonal crosstalk, and (iii) insufficient synaptic input to the axotomized facial motoneurons. As a result, axotomized motoneurons become hyperexcitable but unable to discharge. We review our findings, which have addressed the poor return of mimic function after facial nerve injuries, by testing the hypothesized detrimental component, and we propose that intensifying the trigeminal sensory input to axotomized and electrophysiologically silent facial motoneurons improves the specificity of the reinnervation of appropriate targets. We compared behavioral, functional, and morphological parameters after single reconstructive surgery of the facial nerve (or its buccal branch) with those obtained after identical facial nerve surgery, but combined with direct or indirect stimulation of the ipsilateral infraorbital nerve. We found that both methods of trigeminal sensory stimulation, i.e., stimulation of the vibrissal hairs and manual stimulation of the whisker pad, were beneficial for the outcome through improvement of the quality of target reinnervation and recovery of vibrissal motor performance.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rink-Notzon, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuscher, Jannika UNSPECIFIED UNSPECIFIED UNSPECIFIED Nohroudi, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Manthou, Marilena UNSPECIFIED UNSPECIFIED UNSPECIFIED Gordon, Tessa UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, Doychin N. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680667
DOI:	10.3390/ijms232315101
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	23
Number:	23
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PERIPHERAL-NERVE; BRAIN-STEM; SCIATIC-NERVE; AFFERENT-PROJECTIONS; MYSTACIAL VIBRISSAE; SYNAPSE ELIMINATION; MUSCLE INNERVATION; HYPOGLOSSAL NUCLEI; ACTION-POTENTIALS; HEMIFACIAL SPASM Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68066