Universität zu Köln

Wolf, Florian ORCID: 0000-0003-0777-866X, Nielsen, Joern, Saliger, Jochen, Hennecken, Eva, Eschweiler, Mareike, Folkerts, Ann-Kristin, Karbe, Hans and Zimmer, Philipp (2022). Randomised controlled pilot and feasibility study of multimodal agility-based exercise training (MAT) versus strength and endurance training (SET) to improve multiple sclerosis-related fatigue and fatigability during inpatient rehabilitation (ReFEx): study protocol. BMJ Open, 12 (9). LONDON: BMJ PUBLISHING GROUP. ISSN 2044-6055

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Abstract

Introduction Subjective fatigue and objectively assessed fatigability are common symptoms in persons with multiple sclerosis (pwMS). Recent work has suggested a positive effect of balance and motor control training (BMCT) in reducing fatigue. It is unclear whether this effect can also be attained during inpatient rehabilitation. Multimodal agility-based exercise training (MAT) has been developed as a framework that incorporates BMCT with added agility components but has not been applied to pwMS. Therefore, this study will evaluate the feasibility of a randomised controlled trial comparing MAT against strength and endurance training (SET) for the improvement of MS-related fatigue and fatigability in a German neurological rehabilitation centre. Methods and analysis A total of 24 pwMS (Expanded Disability Status Scale <= 5.0, Fatigue Scale for Motor and Cognitive Functions >= 53) will be randomly assigned to either SET or land and water-based MAT for 4-6 weeks during inpatient rehabilitation. Assessments of subjective fatigue, motor and cognitive fatigability, cognitive and cardiorespiratory performance, and balance confidence will be performed at admission and discharge. Subjective fatigue will also be assessed at 1, 4 and 12 weeks after discharge. Feasibility outcomes will include patients' acceptance of study procedures and interventions, recruitment rate, retention rate, time needed to complete baseline assessments, intervention adherence and fidelity. All quantitative outcomes will be reported descriptively. A total of 12 pwMS (6 per group) will be interviewed to gain insights into participants' experiences during study participation. Ethics and dissemination Ethical approval has been obtained from the Ethics Committee of the University of Bonn (reference number: 543/20). Dissemination of findings is planned via peer-reviewed journals, conferences and media releases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wolf, Florian UNSPECIFIED orcid.org/0000-0003-0777-866X UNSPECIFIED Nielsen, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Saliger, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennecken, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Eschweiler, Mareike UNSPECIFIED UNSPECIFIED UNSPECIFIED Folkerts, Ann-Kristin UNSPECIFIED UNSPECIFIED UNSPECIFIED Karbe, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680968
DOI:	10.1136/bmjopen-2022-062160
Journal or Publication Title:	BMJ Open
Volume:	12
Number:	9
Date:	2022
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2044-6055
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COGNITIVE FUNCTIONS; BALANCE; INSTRUMENT; ABILITY; WALKING; SCALE Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68096