Universität zu Köln

Maekawa, Takaki, Kashkar, Hamid ORCID: 0000-0003-2796-1429 and Coll, Nuria S. . Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants. Cell Death Differ.. LONDON: SPRINGERNATURE. ISSN 1476-5403

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Abstract

Host organisms utilise a range of genetically encoded cell death programmes in response to pathogen challenge. Host cell death can restrict pathogen proliferation by depleting their replicative niche and at the same time dying cells can alert neighbouring cells to prepare environmental conditions favouring future pathogen attacks. As expected, many pathogenic microbes have strategies to subvert host cell death to promote their virulence. The structural and lifestyle differences between animals and plants have been anticipated to shape very different host defence mechanisms. However, an emerging body of evidence indicates that several components of the host-pathogen interaction machinery are shared between the two major branches of eukaryotic life. Many proteins involved in cell death execution or cell death-associated immunity in plants and animals exert direct effects on endomembrane and loss of membrane integrity has been proposed to explain the potential immunogenicity of dying cells. In this review we aim to provide a comparative view on how cell death processes are linked to anti-microbial defence mechanisms in plants and animals and how pathogens interfere with these cell death programmes. In comparison to the several well-defined cell death programmes in animals, immunogenic cell death in plant defence is broadly defined as the hypersensitive response. Our comparative overview may help discerning whether specific types of immunogenic cell death exist in plants, and correspondingly, it may provide new hints for previously undiscovered cell death mechanism in animals.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maekawa, Takaki UNSPECIFIED UNSPECIFIED UNSPECIFIED Kashkar, Hamid UNSPECIFIED orcid.org/0000-0003-2796-1429 UNSPECIFIED Coll, Nuria S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-681170
DOI:	10.1038/s41418-022-01060-6
Journal or Publication Title:	Cell Death Differ.
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1476-5403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FACTOR-INDUCED APOPTOSIS; NLRP3 INFLAMMASOME; IMMUNE RECOGNITION; BACULOVIRUS GENE; NECROPTOSIS; RECEPTOR; PROTEIN; CALCIUM; ACTIVATION; NECROSIS Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68117