Universität zu Köln

Affeldt, Patrick ORCID: 0000-0002-3075-0473, Koehler, Felix Carlo ORCID: 0000-0001-9269-7420, Brensing, Karl August, Adam, Vivien, Burian, Julia, Butt, Linus, Gies, Martin, Grundmann, Franziska, Hinrichs, Steffen, Johannis, Wibke ORCID: 0000-0002-2886-7306, Kalisch, Nils, Meyer-Delpho, Matthias, Oehm, Simon ORCID: 0000-0003-4657-6091, Platen, Eva, Schoeler, Claudia, Heger, Eva, Steger, Gertrud ORCID: 0000-0002-0581-8122, Stippel, Dirk ORCID: 0000-0002-1107-0907, Ziegelhoefer, Aileen, Benzing, Thomas ORCID: 0000-0003-0512-1066, Klein, Florian ORCID: 0000-0003-1376-1792, Kurschat, Christine ORCID: 0000-0002-3646-9471, Mueller, Roman-Ulrich and Di Cristanziano, Veronica (2022). Immune Responses to SARS-CoV-2 Infection and Vaccination in Dialysis Patients and Kidney Transplant Recipients. Microorganisms, 10 (1). BASEL: MDPI. ISSN 2076-2607

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Abstract

Dialysis patients and kidney transplant (KTX) recipients suffer from an impaired immune system and show a decreased response to the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination. We performed a retrospective analysis of 1505 serological SARS-CoV-2 measurements obtained from 887 dialysis patients and 86 KTX recipients. The results were separated by patient subgroups (dialysis/KTX) as well as SARS-CoV-2 status. The latter criterion included SARS-CoV-2-naive patients with or without COVID-19 vaccination and convalescent patients receiving a booster shot. Serologies of 27 vaccinated healthy individuals served as the reference group. Vaccine-induced cellular immune response was quantified by an interferon-gamma release assay in 32 KTX recipients. We determined seroconversion rates of 92.6%, 93.4%, and 71.4% in dialysis patients vaccinated with either BNT162b2, mRNA-1273, or AZD1222, respectively. Vaccination-induced anti-SARS-CoV-2 antibody titers were lower in dialysis patients compared to healthy individuals, and vaccination with mRNA-1273 induced higher titers than BNT162b2. The initial seroconversion rate was 39.5% in KTX recipients vaccinated with BNT162b2. A linear regression model identified medication with mycophenolate-mofetil/mycophenolic acid as an independent risk factor for missing seroconversion. Within a cohort of 32 KTX recipients, cellular and humoral immune reactivity to SARS-CoV-2 was detectable in three patients only. Conclusively, vaccine-induced seroconversion rates were similar in dialysis patients compared to healthy individuals but were strongly impaired in KTX recipients. Anti-SARS-CoV-2 IgG titers elicited by double active immunization were significantly lower in both cohorts compared to healthy individuals, and immune responses to vaccination vanished quickly.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Affeldt, Patrick UNSPECIFIED orcid.org/0000-0002-3075-0473 UNSPECIFIED Koehler, Felix Carlo UNSPECIFIED orcid.org/0000-0001-9269-7420 UNSPECIFIED Brensing, Karl August UNSPECIFIED UNSPECIFIED UNSPECIFIED Adam, Vivien UNSPECIFIED UNSPECIFIED UNSPECIFIED Burian, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Butt, Linus UNSPECIFIED UNSPECIFIED UNSPECIFIED Gies, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Grundmann, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Hinrichs, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Johannis, Wibke UNSPECIFIED orcid.org/0000-0002-2886-7306 UNSPECIFIED Kalisch, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer-Delpho, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Oehm, Simon UNSPECIFIED orcid.org/0000-0003-4657-6091 UNSPECIFIED Platen, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoeler, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Heger, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Steger, Gertrud UNSPECIFIED orcid.org/0000-0002-0581-8122 UNSPECIFIED Stippel, Dirk UNSPECIFIED orcid.org/0000-0002-1107-0907 UNSPECIFIED Ziegelhoefer, Aileen UNSPECIFIED UNSPECIFIED UNSPECIFIED Benzing, Thomas UNSPECIFIED orcid.org/0000-0003-0512-1066 UNSPECIFIED Klein, Florian UNSPECIFIED orcid.org/0000-0003-1376-1792 UNSPECIFIED Kurschat, Christine UNSPECIFIED orcid.org/0000-0002-3646-9471 UNSPECIFIED Mueller, Roman-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-681459
DOI:	10.3390/microorganisms10010004
Journal or Publication Title:	Microorganisms
Volume:	10
Number:	1
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-2607
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEMODIALYSIS-PATIENTS; COVID-19 VACCINE; LONGEVITY; DISEASE Multiple languages Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68145