Universität zu Köln

Theis, Hendrik, Probst, Catharina, Campabadal, Anna, Goerlich, Katharina S., Granert, Oliver, Wolff, Stephan, Witt, Karsten, Deuschl, Gunther ORCID: 0000-0002-4176-9196 and van Eimeren, Thilo (2022). Inhibitory framing in hypersexual patients with Parkinson's disease. An fMRI pilot study. Exp. Brain Res., 240 (7-8). S. 2097 - 2108. NEW YORK: SPRINGER. ISSN 1432-1106

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Abstract

Hypersexuality in medicated patients with PD is caused by an increased influence of motivational drive areas and a decreased influence of inhibitory control areas due to dopaminergic medication. In this pilot study, we test a newly developed paradigm investigating the influence of dopaminergic medication on brain activation elicited by sexual pictures with and without inhibitory contextual framing. Twenty PD patients with and without hypersexuality were examined with fMRI either OFF or ON standardized dopaminergic medication. The paradigm consisted of a priming phase where either a neutral context or an inhibitory context was presented. This priming phase was either followed by a sexual or a neutral target. Sexual, compared to neutral pictures resulted in a BOLD activation of various brain regions implicated in sexual processing. Hypersexual PD patients showed increased activity compared to PD controls in these regions. There was no relevant effect of medication between the two groups. The inhibitory context elicited less activation in inhibition-related areas in hypersexual PD, but had no influence on the perception of sexual cues. The paradigm partially worked: reactivity of motivational brain areas to sexual cues was increased in hypersexual PD and inhibitory contextual framing lead to decreased activation of inhibitory control areas in PD. We could not find a medication effect and the length of the inhibitory stimulus was not optimal to suppress reactivity to sexual cues. Our data provide new insights into the mechanisms of hypersexuality and warrant a replication with a greater cohort and an optimized stimulus length in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Theis, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Probst, Catharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Campabadal, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Goerlich, Katharina S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Granert, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolff, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Witt, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Deuschl, Gunther UNSPECIFIED orcid.org/0000-0002-4176-9196 UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-681625
DOI:	10.1007/s00221-022-06397-5
Journal or Publication Title:	Exp. Brain Res.
Volume:	240
Number:	7-8
Page Range:	S. 2097 - 2108
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1106
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMPULSIVE-COMPULSIVE DISORDERS; SEXUAL AROUSAL; QUESTIONNAIRE; ACTIVATION; RESPONSES; SEEKING; SCALES Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68162