Universität zu Köln

Doppler, Christopher E. J., Meyer, Linda, Seger, Aline, Karges, Wolfram, Weiss, Peter H. ORCID: 0000-0002-5230-9080 and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2022). Intranasal oxytocin attenuates the effects of monetary feedback on procedural learning. Psychoneuroendocrinology, 143. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-3360

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Abstract

Procedural learning is a vital brain function that allows us to acquire motor skills during development or re-learn them after lesions affecting the motor system. Procedural learning can be improved by feedback of different valence, e.g., monetary or social, mediated by dopaminergic circuits. While processing motivationally relevant stimuli, dopamine interacts closely with oxytocin, whose effects on procedural learning, particularly feedbackbased approaches, remain poorly understood. In a randomized, double-blind, placebo-controlled trial, we investigated whether oxytocin modulates the differential effects of monetary and social feedback on procedural learning. Sixty-one healthy male participants were randomized to receive a placebo or oxytocin intranasally. The participants then performed a modified serial reaction time task. Oxytocin plasma concentrations were measured before and after applying the placebo or verum. Groups did not differ regarding general reaction times or measures of procedural learning. For the placebo group, monetary feedback improved procedural learning compared to a neutral control condition. In contrast, the oxytocin group did not show a differential effect of monetary or social feedback despite a significant increase in oxytocin plasma levels after intranasal application. The data suggest that oxytocin does not influence procedural learning per se. Instead, oxytocin seems to attenuate the effects of monetary feedback on procedural learning specifically.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Doppler, Christopher E. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Seger, Aline UNSPECIFIED UNSPECIFIED UNSPECIFIED Karges, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-681717
DOI:	10.1016/j.psyneuen.2022.105823
Journal or Publication Title:	Psychoneuroendocrinology
Volume:	143
Date:	2022
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-3360
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SOCIAL REWARD; PUNISHMENT; MEMORY; VASOPRESSIN; HYPOTHESIS; MIDBRAIN Multiple languages Endocrinology & Metabolism; Neurosciences; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68171