Universität zu Köln

Robilotti, Elizabeth, V, Whiting, Karissa, Lucca, Anabella, Poon, Chester, Guest, Rebecca, McMillen, Tracy ORCID: 0000-0002-0383-1366, Jani, Krupa ORCID: 0000-0002-6536-3879, Solovyov, Alexander, Kelson, Suzanne, Browne, Kevin, Freeswick, Scott, Hohl, Tobias M., Korenstein, Deborah, Ruchnewitz, Denis, Lassig, Michael, Luksza, Marta, Greenbaum, Benjamin, Seshan, Venkatraman E., Babady, N. Esther and Kamboj, Mini (2022). Clinical and Genomic Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Infections in mRNA Vaccinated Health Care Personnel in New York City. Clin. Infect. Dis., 75 (1). S. E774 - 9. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6591

Full text not available from this repository.

Abstract

Background Vaccine-induced clinical protection against severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) variants is an evolving target. There are limited genomic level data on SARS CoV-2 breakthrough infections and vaccine effectiveness (VE) since the global spread of the B.1.617.2 (Delta) variant. Methods In a retrospective study from 1 November 2020 to 31 August 2021, divided as pre-Delta and Delta-dominant periods, laboratory-confirmed SARS CoV-2 infections among healthcare personnel (HCP) at a large tertiary cancer center in New York City were examined to compare the weekly infection rate-ratio in vaccinated, partially vaccinated, and unvaccinated HCP. We describe the clinical and genomic epidemiologic features of post-vaccine infections to assess for selection of variants of concern (VOC)/variants of interest (VOI) in the early post-vaccine period and impact of B.1.617.2 (Delta) variant domination on VE. Results Among 13658 HCP in our cohort, 12379 received at least 1 dose of a messenger RNA (mRNA) vaccine. In the pre-Delta period overall VE was 94.5%. Whole genome sequencing (WGS) of 369 isolates in the pre-Delta period did not reveal a clade bias for VOC/VOI specific to post-vaccine infections. VE in the Delta dominant phase was 75.6%. No hospitalizations occurred among vaccinated HCP in the entire study period, compared to 17 hospitalizations and 1 death among unvaccinated HCP. Conclusions Findings show high VE among HCP in New York City in the pre-Delta phase, with moderate decline in VE post-Delta emergence. SARS CoV-2 clades were similarly distributed among vaccinated and unvaccinated infected HCP without apparent clustering during the pre-Delta period of diverse clade circulation. Strong vaccine protection against hospitalization was maintained through the entire study period. study of >13000 healthcare personnel (HCP) showed that messenger RNA (mRNA) vaccine effectiveness (VE) against coronavirus disease 2019 (COVID-19) was 94% through initial 5 months of follow-up, with moderate VE reduction to 75% during subsequent Delta-dominant period. No hospitalizations occurred among vaccinated HCP throughout the study period.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Robilotti, Elizabeth, V UNSPECIFIED UNSPECIFIED UNSPECIFIED Whiting, Karissa UNSPECIFIED UNSPECIFIED UNSPECIFIED Lucca, Anabella UNSPECIFIED UNSPECIFIED UNSPECIFIED Poon, Chester UNSPECIFIED UNSPECIFIED UNSPECIFIED Guest, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED McMillen, Tracy UNSPECIFIED orcid.org/0000-0002-0383-1366 UNSPECIFIED Jani, Krupa UNSPECIFIED orcid.org/0000-0002-6536-3879 UNSPECIFIED Solovyov, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Kelson, Suzanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Browne, Kevin UNSPECIFIED UNSPECIFIED UNSPECIFIED Freeswick, Scott UNSPECIFIED UNSPECIFIED UNSPECIFIED Hohl, Tobias M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Korenstein, Deborah UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruchnewitz, Denis UNSPECIFIED UNSPECIFIED UNSPECIFIED Lassig, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Luksza, Marta UNSPECIFIED UNSPECIFIED UNSPECIFIED Greenbaum, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Seshan, Venkatraman E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Babady, N. Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamboj, Mini UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-682640
DOI:	10.1093/cid/ciab886
Journal or Publication Title:	Clin. Infect. Dis.
Volume:	75
Number:	1
Page Range:	S. E774 - 9
Date:	2022
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1537-6591
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PREVENTING SARS-COV-2 INFECTION; 8 US LOCATIONS; COVID-19 VACCINES; FRONTLINE WORKERS; VARIANT Multiple languages Immunology; Infectious Diseases; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68264