Universität zu Köln

Wollring, Michael M., Werner, Jan-Michael ORCID: 0000-0001-7147-4594, Ceccon, Garry, Lohmann, Philipp, Filss, Christian P., Fink, Gereon R. ORCID: 0000-0002-8230-1856, Langen, Karl-Josef and Galldiks, Norbert . Clinical applications and prospects of PET imaging in patients with IDH-mutant gliomas. J. Neuro-Oncol.. NEW YORK: SPRINGER. ISSN 1573-7373

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Abstract

PET imaging using radiolabeled amino acids in addition to MRI has become a valuable diagnostic tool in the clinical management of patients with brain tumors. This review provides a comprehensive overview of PET studies in glioma patients with a mutation in the isocitrate dehydrogenase gene (IDH). A considerable fraction of these tumors typically show no contrast enhancement on MRI, especially when classified as grade 2 according to the World Health Organization classification of Central Nervous System tumors. Major diagnostic challenges in this situation are differential diagnosis, target definition for diagnostic biopsies, delineation of glioma extent for treatment planning, differentiation of treatment-related changes from tumor progression, and the evaluation of response to alkylating agents. The main focus of this review is the role of amino acid PET in this setting. Furthermore, in light of clinical trials using IDH inhibitors targeting the mutated IDH enzyme for treating patients with IDH-mutant gliomas, we also aim to give an outlook on PET probes specifically targeting the IDH mutation, which appear potentially helpful for response assessment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wollring, Michael M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Jan-Michael UNSPECIFIED orcid.org/0000-0001-7147-4594 UNSPECIFIED Ceccon, Garry UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohmann, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Filss, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Langen, Karl-Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-682799
DOI:	10.1007/s11060-022-04218-x
Journal or Publication Title:	J. Neuro-Oncol.
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1573-7373
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; CENTRAL-NERVOUS-SYSTEM; F-18-FET PET; BRAIN-TUMOR; RESPONSE ASSESSMENT; GLIOBLASTOMA; MRI; PSEUDOPROGRESSION; NEUROONCOLOGY; DIAGNOSIS Multiple languages Oncology; Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68279