Universität zu Köln

Augustin, Max ORCID: 0000-0002-2300-9337, Horn, Carola, Ercanoglu, Meryem Seda, de Silva, Ute Sandaradura, Bondet, Vincent, Suarez, Isabelle, Chon, Seung-Hun ORCID: 0000-0002-8923-6428, Nierhoff, Dirk, Knops, Elena ORCID: 0000-0001-7398-3026, Heger, Eva, Vivaldi, Carlo, Schaefer, Hartmut, Oette, Mark, Faetkenheuer, Gerd, Klein, Florian ORCID: 0000-0003-1376-1792, Duffy, Darragh ORCID: 0000-0002-8875-2308, Muller-Trutwin, Michaela and Lehmann, Clara (2022). CXCR3 Expression Pattern on CD4+ T Cells and IP-10 Levels with Regard to the HIV-1 Reservoir in the Gut-Associated Lymphatic Tissue. Pathogens, 11 (4). BASEL: MDPI. ISSN 2076-0817

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Abstract

(1) Background: The gut-associated lymphatic tissue (GALT) represents the largest lymphoid organ, and is considered to be the largest HIV reservoir. The exact size of the GALT reservoir remains unclear. Several markers, such as the chemokine receptor CXCR3 and its pro-inflammatory ligand IP-10, have been proposed to define the size of HIV reservoirs in the peripheral blood (PB). However, little is known about the role of CXCR3 and IP-10 within the GALT. (2) Methods: We compared the CXCR3 expression, IP-10 levels, and cell-associated HIV DNA of distinct memory CD4+ T cell subsets from the terminal ileum (TI), PB and rectum (RE) of 18 HIV+ patients with antiretroviral therapy (ART), 6 HIV+ treatment-naive patients and 16 healthy controls. (3) Results: While the relative distributions of CD4+ T cell subsets were similar in PB, TI and RE, HIV DNA and CXCR3 expression were markedly increased and IP-10 levels were decreased in TI when compared to PB. No significant correlation was found between the CXCR3 expression and memory CD4+ T cell subsets, IP-10 levels and the HIV DNA amounts measured in PB, TI or RE. (4) Conclusions: During a chronic HIV-1 infection, neither CXCR3 nor IP-10 are indicative of the size of the viral reservoir in the GALT (TI and RE).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Augustin, Max UNSPECIFIED orcid.org/0000-0002-2300-9337 UNSPECIFIED Horn, Carola UNSPECIFIED UNSPECIFIED UNSPECIFIED Ercanoglu, Meryem Seda UNSPECIFIED UNSPECIFIED UNSPECIFIED de Silva, Ute Sandaradura UNSPECIFIED UNSPECIFIED UNSPECIFIED Bondet, Vincent UNSPECIFIED UNSPECIFIED UNSPECIFIED Suarez, Isabelle UNSPECIFIED UNSPECIFIED UNSPECIFIED Chon, Seung-Hun UNSPECIFIED orcid.org/0000-0002-8923-6428 UNSPECIFIED Nierhoff, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Knops, Elena UNSPECIFIED orcid.org/0000-0001-7398-3026 UNSPECIFIED Heger, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Vivaldi, Carlo UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer, Hartmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Oette, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED orcid.org/0000-0003-1376-1792 UNSPECIFIED Duffy, Darragh UNSPECIFIED orcid.org/0000-0002-8875-2308 UNSPECIFIED Muller-Trutwin, Michaela UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Clara UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-682836
DOI:	10.3390/pathogens11040483
Journal or Publication Title:	Pathogens
Volume:	11
Number:	4
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-0817
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LYMPHOID-TISSUE; ANTIRETROVIRAL THERAPY; INFECTED INDIVIDUALS; POSITIVE PATIENTS; PERSISTENCE; BLOOD; DEPLETION; DNA; RESTORATION; ACTIVATION Multiple languages Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68283