Universität zu Köln

Oudmaijer, C. A. J., Minnee, R. C., Pol, R. A., van den Boogaard, W. M. C., Komninos, D. S. J., van de Wetering, J., van Heugten, M. H., Hoorn, E. J., Sanders, J. S. F., Hoeijmakers, J. H. J., Vermeij, W. P. and IJzermans, J. N. M. (2022). Fasting before living-kidney donation: effect on donor well-being and postoperative recovery: study protocol of a multicenter randomized controlled trial. Trials, 23 (1). LONDON: BMC. ISSN 1745-6215

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Abstract

Background: One of the main effectors on the quality of life of living-kidney donors is postoperative fatigue. Caloric restriction (CR) and short-term fasting (STF) are associated with improved fitness and increased resistance to acute stress. CR/STF increases the expression of cytoprotective genes, increases immunomodulation via increased anti-inflammatory cytokine production, and decreases the expression of pro-inflammatory markers. As such, nutritional preconditioning by CR or STF represents a non-invasive and cost-effective method that could mitigate the effects of acute surgery-induced stress and postoperative fatigue. To investigate whether preoperative STF contributes to a reduction in fatigue after living-kidney donation, a randomized clinical trial is indicated. Methods: We aim to determine whether 2.5 days of fasting reduces postoperative fatigue score in subjects undergoing living-kidney donation. In this randomized study, the intervention group will follow a preoperative fasting regime for 2.5 days with a low-dose laxative, while the control group will receive standard care. The main study endpoint is postoperative fatigue, 4 weeks after living-kidney donation. Secondary endpoints include the effect of preoperative fasting on postoperative hospital admission time, the feasibility of STF, and the postoperative recovery of donor and recipient kidney function. This study will provide us with knowledge of the feasibility of STF and confirm its effect on postoperative recovery. Discussion: Our study will provide clinically relevant information on the merits of caloric restriction for living-kidney donors and recipients. We expect to reduce the postoperative fatigue in living-kidney donors and improve the postoperative recovery of living-kidney recipients. It will provide evidence on the clinical merits and potential caveats of preoperative dietary interventions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Oudmaijer, C. A. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Minnee, R. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pol, R. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED van den Boogaard, W. M. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Komninos, D. S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED van de Wetering, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Heugten, M. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoorn, E. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sanders, J. S. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeijmakers, J. H. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vermeij, W. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED IJzermans, J. N. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-682923
DOI:	10.1186/s13063-021-05950-x
Journal or Publication Title:	Trials
Volume:	23
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1745-6215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TERM DIETARY RESTRICTION; QUALITY-OF-LIFE; ISCHEMIA-REPERFUSION; ENHANCED RECOVERY; CALORIC RESTRICTION; COLORECTAL SURGERY; INJURY; STRESS Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68292