Universität zu Köln

Slotman, Derk J., Bartels, Lambertus W., Zijlstra, Aylene, Verpalen, Inez M., van Osch, Jochen A. C., Nijholt, Ingrid M., Heijman, Edwin, van 't Veer-ten Kate, Miranda, de Boer, Erwin, van den Hoed, Rolf D., Froeling, Martijn ORCID: 0000-0003-3841-0497 and Boomsma, Martijn F. . Diffusion-weighted MRI with deep learning for visualizing treatment results of MR-guided HIFU ablation of uterine fibroids. Eur. Radiol.. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

ObjectivesNo method is available to determine the non-perfused volume (NPV) repeatedly during magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) ablations of uterine fibroids, as repeated acquisition of contrast-enhanced T1-weighted (CE-T1w) scans is inhibited by safety concerns. The objective of this study was to develop and test a deep learning-based method for translation of diffusion-weighted imaging (DWI) into synthetic CE-T1w scans, for monitoring MR-HIFU treatment progression. MethodsThe algorithm was retrospectively trained and validated on data from 33 and 20 patients respectively who underwent an MR-HIFU treatment of uterine fibroids between June 2017 and January 2019. Postablation synthetic CE-T1w images were generated by a deep learning network trained on paired DWI and reference CE-T1w scans acquired during the treatment procedure. Quantitative analysis included calculation of the Dice coefficient of NPVs delineated on synthetic and reference CE-T1w scans. Four MR-HIFU radiologists assessed the outcome of MR-HIFU treatments and NPV ratio based on the synthetic and reference CE-T1w scans. ResultsDice coefficient of NPVs was 71% (& PLUSMN; 22%). The mean difference in NPV ratio was 1.4% (& PLUSMN; 22%) and not statistically significant (p = 0.79). Absolute agreement of the radiologists on technical treatment success on synthetic and reference CE-T1w scans was 83%. NPV ratio estimations on synthetic and reference CE-T1w scans were not significantly different (p = 0.27). ConclusionsDeep learning-based synthetic CE-T1w scans derived from intraprocedural DWI allow gadolinium-free visualization of the predicted NPV, and can potentially be used for repeated gadolinium-free monitoring of treatment progression during MR-HIFU therapy for uterine fibroids.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Slotman, Derk J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartels, Lambertus W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zijlstra, Aylene UNSPECIFIED UNSPECIFIED UNSPECIFIED Verpalen, Inez M. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Osch, Jochen A. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nijholt, Ingrid M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heijman, Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED van 't Veer-ten Kate, Miranda UNSPECIFIED UNSPECIFIED UNSPECIFIED de Boer, Erwin UNSPECIFIED UNSPECIFIED UNSPECIFIED van den Hoed, Rolf D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Froeling, Martijn UNSPECIFIED orcid.org/0000-0003-3841-0497 UNSPECIFIED Boomsma, Martijn F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-682930
DOI:	10.1007/s00330-022-09294-1
Journal or Publication Title:	Eur. Radiol.
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTENSITY FOCUSED ULTRASOUND; LEIOMYOMATA; SURGERY; LINK Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68293