Universität zu Köln

Ju, Feng, Atyah, Manar M., Horstmann, Nellie, Gul, Sheraz, Vago, Razi, Bruns, Christiane J., Zhao, Yue, Dong, Qiong-Zhu and Ren, Ning (2022). Characteristics of the cancer stem cell niche and therapeutic strategies. Stem Cell Res. Ther., 13 (1). LONDON: BMC. ISSN 1757-6512

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Abstract

Distinct regions harboring cancer stem cells (CSCs) have been identified within the microenvironment of various tumors, and as in the case of their healthy counterparts, these anatomical regions are termed niche. Thus far, a large volume of studies have shown that CSC niches take part in the maintenance, regulation of renewal, differentiation and plasticity of CSCs. In this review, we summarize and discuss the latest findings regarding CSC niche morphology, physical terrain, main signaling pathways and interactions within them. The cellular and molecular components of CSCs also involve genetic and epigenetic modulations that mediate and support their maintenance, ultimately leading to cancer progression. It suggests that the crosstalk between CSCs and their niche plays an important role regarding therapy resistance and recurrence. In addition, we updated diverse therapeutic strategies in different cancers in basic research and clinical trials in this review. Understanding the complex heterogeneity of CSC niches is a necessary pre-requisite for designing superior therapeutic strategies to target CSC-specific factors and/or components of the CSC niche.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ju, Feng UNSPECIFIED UNSPECIFIED UNSPECIFIED Atyah, Manar M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Horstmann, Nellie UNSPECIFIED UNSPECIFIED UNSPECIFIED Gul, Sheraz UNSPECIFIED UNSPECIFIED UNSPECIFIED Vago, Razi UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Yue UNSPECIFIED UNSPECIFIED UNSPECIFIED Dong, Qiong-Zhu UNSPECIFIED UNSPECIFIED UNSPECIFIED Ren, Ning UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-683090
DOI:	10.1186/s13287-022-02904-1
Journal or Publication Title:	Stem Cell Res. Ther.
Volume:	13
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1757-6512
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH-FACTOR-BETA; BREAST-CANCER; DRUG-RESISTANCE; SIGNALING PATHWAYS; BCRP EXPRESSION; PROSTATE-CANCER; UP-REGULATION; T-CELLS; HYPOXIA Multiple languages Cell & Tissue Engineering; Cell Biology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68309