Universität zu Köln

Gerlach, Darius A., Maier, Andrea, Manuel, Jorge ORCID: 0000-0003-1983-1448, Bach, Anja, Hoff, Alex, Hoenemann, Jan-Niklas, Heusser, Karsten ORCID: 0000-0002-2571-5585, Voit, Dirk, Frahm, Jens ORCID: 0000-0002-8279-884X, Jordan, Jens ORCID: 0000-0003-4518-0706 and Tank, Jens (2022). Real-Time Magnetic Resonance Imaging to Study Orthostatic Intolerance Mechanisms in Human Beings: Proof of Concept. J. Am. Heart Assoc., 11 (21). HOBOKEN: WILEY. ISSN 2047-9980

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Abstract

Background Discerning the mechanisms driving orthostatic symptoms in human beings remains challenging. Therefore, we developed a novel approach combining cardiac and cerebral real-time magnetic resonance imaging, beat-to-beat physiological monitoring, and orthostatic stress testing through lower-body negative pressure (LBNP). We conducted a proof-of-concept study in a patient with severe orthostatic hypotension. Methods and Results We included a 46-year-old man with pure autonomic failure. Without and during -30 mmHg LBNP, we obtained 3T real-time magnetic resonance imaging of the cardiac short axis and quantitative flow measurements in the pulmonary trunk and middle cerebral artery. Blood pressure was 118/74 mmHg during supine rest and 58/35 mmHg with LBNP. With LBNP, left ventricular stroke volume decreased by 44.6%, absolute middle cerebral artery flow by 37.6%, and pulmonary trunk flow by 40%. Conclusions Combination of real-time magnetic resonance imaging, LBNP, and continuous blood pressure monitoring provides a promising new approach to study orthostatic intolerance mechanisms in human beings.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gerlach, Darius A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Manuel, Jorge UNSPECIFIED orcid.org/0000-0003-1983-1448 UNSPECIFIED Bach, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoff, Alex UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoenemann, Jan-Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Heusser, Karsten UNSPECIFIED orcid.org/0000-0002-2571-5585 UNSPECIFIED Voit, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Frahm, Jens UNSPECIFIED orcid.org/0000-0002-8279-884X UNSPECIFIED Jordan, Jens UNSPECIFIED orcid.org/0000-0003-4518-0706 UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-683417
DOI:	10.1161/JAHA.122.026437
Journal or Publication Title:	J. Am. Heart Assoc.
Volume:	11
Number:	21
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2047-9980
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PURE AUTONOMIC FAILURE; HEAD-UP TILT; MRI; RESPONSES; FLOW Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68341