Universität zu Köln

Jonas, Jost B., Yan, Yan Ni, Zhang, Qi, Zhang, Qing, Wei, Wen Bin, Jonas, Rahul A. and Wang, Ya Xing (2022). Retinal nerve fibre layer thickness in association with gamma zone width and disc-fovea distance. Acta Ophthalmol., 100 (6). S. 632 - 640. HOBOKEN: WILEY. ISSN 1755-3768

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Abstract

Purpose Previous studies have shown that the retinal nerve fibre layer (RNFL) thickness as surrogate of the optic nerve decreases with longer axial length. We explored which explanatory parameters might explain that association. Methods Participants of the population-based Beijing Eye Study 2011 without any retinal or optic nerve disease were selected based on a refractive error-based stratified randomization. Results The study included of 632 participants (age: 59.1 +/- 7.3 years; axial length: 23.5 +/- 1.2 mm; range: 20.88-28.68 mm). Thicker RNFL (mean: 101.0 +/- 10.0 mu m) was associated (multivariable analysis) with smaller parapapillary gamma zone (defined as Bruch's membrane-free parapapillary region) (standardized regression coefficient beta: -0.13; non-stadardized regression coefficient B: -0.008; 95% confidence interval (CI): -0.014, -0.003; p = 0.005) and shorter disc-fovea distance (beta: -0.15; B: -3.91; 95% CI: -6.60; -1.22; p = 0.004), after adjusting for age (beta: -0.22; B: -030; 95% CI: -0.41, -0.19; p < 0.001), gender (beta: 0.12; B: 2.37; 95% CI 0.77, 3.97; p = 0.004) and larger optic disc area (beta: 0.12; B: 0.12; 95% CI: 2.14; 95% CI: 0.54, 3.73; p = 0.009). RNFL thickness decreased by 8 mu m (95% CI: 3, 14) for each mm increase in gamma zone width, and by 3.91 mu m (95% CI: 1.22, 6.60) for each mm elongation of the disc-fovea distance. If disc-fovea distance and gamma zone width were replaced by axial length, the latter was correlated with RNFL thickness (beta: -0.37; B: -3.12; 95% CI: -3.88, -2.35; p < 0.001). Longer disc-fovea distance was directly associated with larger gamma zone (beta: 0.50; B: p < 0.001). Conclusions The RNFL thickness decrease with longer axial length is associated with a longer optic disc-fovea distance and larger parapapillary gamma zone. Longer disc-fovea distance and larger gamma zone lead to an elongation and stretching of the retinal nerve fibres, potentially causing a thinning or loss of the nerve fibres. It may explain the occurrence of visual field defects in some non-glaucomatous highly myopic eyes without macular correlates of the perimetric defects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jonas, Jost B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yan, Yan Ni UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Qi UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Qing UNSPECIFIED UNSPECIFIED UNSPECIFIED Wei, Wen Bin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonas, Rahul A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Ya Xing UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-683988
DOI:	10.1111/aos.15088
Journal or Publication Title:	Acta Ophthalmol.
Volume:	100
Number:	6
Page Range:	S. 632 - 640
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1755-3768
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; AXIAL LENGTH; BEIJING EYE; SIZE; POPULATION; AGE; DETERMINANTS; FUNDUS; COUNT Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68398