Universität zu Köln

Siebert, Stefan ORCID: 0000-0002-6420-0402, Leopold, Karolina, Baumgardt, Johanna, Von Hardenberg, Laura-Sophie, Burkhardt, Eva and Bechdolf, Andreas (2022). Specialized inpatient treatment for young people with early psychosis: acute-treatment and 12-month results. Eur. Arch. Psych. Clin. Neurosci., 272 (7). S. 1 - 15. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

The objective of the study was to investigate the development of clinical outcomes of young people with early psychosis in a specialized inpatient treatment and assess the feasibility of such an intervention in an inpatient setting. The study was a prospective cohort study of patients with early psychosis treated at the specialized inpatient treatment Fuhinterventions-und Therapiezentrum, FRITZ (early intervention and therapy center) in Berlin, Germany. The primary outcomes were attitudes towards psychiatric medication and patient satisfaction with treatment after 6 weeks. Secondary outcomes were clinical symptoms, functioning, remission, recovery, all-cause treatment discontinuation, and rehospitalisation at 6 and 12 months after inpatient treatment. We recruited 95 inpatients with early psychosis. Attitudes towards psychiatric medication (Delta(6weeks) = 3.00, d(6weeks) = 0.55; Delta(6mo) = 2.15, d(6mo) = 0.35; Delta(12mo) = 3.03, d(12mo) = 0.52) and patient satisfaction (Delta(6weeks) = 0.21, d(6weeks) = 0.40; Delta(6mo) = 0.32, d(6mo) = 0.43; Delta(12mo) = 0.13, d(12mo) = 0.17) changed with medium effect sizes at six weeks up to a 6- and 12-month follow-up. Clinical outcomes changed significantly with medium-to-large-effect sizes over 12 months CGI(Delta 12mo) = 1.64, d(12mo) = -1.12; PANSS total(Delta 12mo) = 20.10, d(12mo) = -0.76; GAF(Delta 12mo) = 19.58, d(12mo) = 1.25). The all-cause treatment discontinuation rate was 13.69% (n = 13) at a 6-month and 35.79% (n = 34) at a 12-month follow-up. The rehospitalization rate was 30.53% (n = 29) at a 6-month and 43.16% (n = 41) at a 12-month follow-up. Patients with specialized inpatient treatment for early psychosis showed improvements in attitude towards psychiatric medication, patient satisfaction, symptoms, and functioning for up to 12 months.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Siebert, Stefan UNSPECIFIED orcid.org/0000-0002-6420-0402 UNSPECIFIED Leopold, Karolina UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumgardt, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Von Hardenberg, Laura-Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Burkhardt, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechdolf, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-684108
DOI:	10.1007/s00406-022-01379-8
Journal or Publication Title:	Eur. Arch. Psych. Clin. Neurosci.
Volume:	272
Number:	7
Page Range:	S. 1 - 15
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-8491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COGNITIVE-BEHAVIORAL THERAPY; 1ST-EPISODE PSYCHOSIS; EARLY INTERVENTION; 1ST EPISODE; ANTIPSYCHOTIC MEDICATION; CLINICAL-OUTCOMES; SCHIZOPHRENIA; TRIAL; SERVICES; SATISFACTION Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68410