Saggau, Carina, Martini, Gabriela Rios, Rosati, Elisa ORCID: 0000-0002-2635-6422, Meise, Silja, Messner, Berith, Kamps, Ann-Kristin, Bekel, Nicole, Gigla, Johannes, Rose, Ruben ORCID: 0000-0003-0657-2993, Voss, Mathias, Geisen, Ulf M., Reid, Hayley M., Sumbul, Melike, Tran, Florian, Berner, Dennis K., Khodamoradi, Yascha ORCID: 0000-0001-5972-0967, Vehreschild, Maria J. G. T., Cornely, Oliver, Koehler, Philipp, Krumbholz, Andi, Fickenscher, Helmut, Kreuzer, Oliver, Schreiber, Claudia, Franke, Andre, Schreiber, Stefan, Hoyer, Bimba, Scheffold, Alexander ORCID: 0000-0002-0626-343X and Bacher, Petra ORCID: 0000-0003-4264-6451 (2022). The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination. Immunity, 55 (10). S. 1924 - 1946. CAMBRIDGE: CELL PRESS. ISSN 1097-4180

Full text not available from this repository.

Abstract

SARS-CoV-2 infection and vaccination generates enormous host-response heterogeneity and an age -dependent loss of immune-response quality. How the pre-exposure T cell repertoire contributes to this heterogeneity is poorly understood. We combined analysis of SARS-CoV-2-specific CD4+ T cells pre-and post-vaccination with longitudinal T cell receptor tracking. We identified strong pre-exposure T cell variability that correlated with subsequent immune-response quality and age. High-quality responses, defined by strong expansion of high-avidity spike-specific T cells, high interleukin-21 production, and specific immuno-globulin G, depended on an intact naive repertoire and exclusion of pre-existing memory T cells. In the elderly, T cell expansion from both compartments was severely compromised. Our results reveal that an intrinsic defect of the CD4+ T cell repertoire causes the age-dependent decline of immune-response quality against SARS-CoV-2 and highlight the need for alternative strategies to induce high-quality T cell responses against newly arising pathogens in the elderly.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Saggau, CarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martini, Gabriela RiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosati, ElisaUNSPECIFIEDorcid.org/0000-0002-2635-6422UNSPECIFIED
Meise, SiljaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Messner, BerithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamps, Ann-KristinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bekel, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gigla, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rose, RubenUNSPECIFIEDorcid.org/0000-0003-0657-2993UNSPECIFIED
Voss, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geisen, Ulf M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reid, Hayley M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sumbul, MelikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tran, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berner, Dennis K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khodamoradi, YaschaUNSPECIFIEDorcid.org/0000-0001-5972-0967UNSPECIFIED
Vehreschild, Maria J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krumbholz, AndiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fickenscher, HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreuzer, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schreiber, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schreiber, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoyer, BimbaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheffold, AlexanderUNSPECIFIEDorcid.org/0000-0002-0626-343XUNSPECIFIED
Bacher, PetraUNSPECIFIEDorcid.org/0000-0003-4264-6451UNSPECIFIED
URN: urn:nbn:de:hbz:38-684278
DOI: 10.1016/j.immuni.2022.08.003
Journal or Publication Title: Immunity
Volume: 55
Number: 10
Page Range: S. 1924 - 1946
Date: 2022
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1097-4180
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NAIVE; DIVERSITY; FREQUENCY; SPECIFICITY; AGEMultiple languages
ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/68427

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item