Universität zu Köln

Doppler, Christopher E. J., Smit, Julia, Hommelsen, Maximilian, Seger, Aline, Okkels, Niels ORCID: 0000-0002-6483-9505, Horsager, Jacob, Kinnerup, Martin, Hansen, Allan K., Fedorova, Tatyana D., Knudsen, Karoline, Otto, Marit, Nahimi, Adjmal, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Borghammer, Per ORCID: 0000-0001-6391-8052 and Sommerauer, Michael (2022). Disruption of Sleep Microarchitecture Is a Sensitive and Early Marker of Parkinson's Disease. J. Parkinsons Dis., 12 (8). S. 2555 - 2561. AMSTERDAM: IOS PRESS. ISSN 1877-718X

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Abstract

Background: Although sleep disturbances are highly prevalent in patients with Parkinson's disease, sleep macroarchitecture metrics show only minor changes. Objective: To assess alterations of the cyclic alternating pattern (CAP) as a critical feature of sleep microarchitecture in patients with prodromal, recent, and established Parkinson's disease. Methods: We evaluated overnight polysomnography for classic sleep macroarchitecture and CAP metrics in 68 patients at various disease stages and compared results to 22 age- and sex-matched controls. Results: Already at the prodromal stage, patients showed a significantly reduced CAP rate as a central characteristic of sleep microarchitecture. Temporal characteristics of CAP showed a gradual change over disease stages and correlated with motor performance. In contrast, the sleep macroarchitecture metrics did not differ between groups. Conclusion: Data suggest that alterations of sleep microarchitecture are an early and more sensitive characteristic of Parkinson's disease than changes in sleep macroarchitecture.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Doppler, Christopher E. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smit, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hommelsen, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Seger, Aline UNSPECIFIED UNSPECIFIED UNSPECIFIED Okkels, Niels UNSPECIFIED orcid.org/0000-0002-6483-9505 UNSPECIFIED Horsager, Jacob UNSPECIFIED UNSPECIFIED UNSPECIFIED Kinnerup, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansen, Allan K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fedorova, Tatyana D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knudsen, Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Otto, Marit UNSPECIFIED UNSPECIFIED UNSPECIFIED Nahimi, Adjmal UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Borghammer, Per UNSPECIFIED orcid.org/0000-0001-6391-8052 UNSPECIFIED Sommerauer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-684712
DOI:	10.3233/JPD-223442
Journal or Publication Title:	J. Parkinsons Dis.
Volume:	12
Number:	8
Page Range:	S. 2555 - 2561
Date:	2022
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1877-718X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYCLIC ALTERNATING PATTERN Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68471