Universität zu Köln

Rebholz, Heike, Braun, Ralf J., Saha, Titas, Harzer, Oliver, Schneider, Miriam ORCID: 0000-0003-2689-8317 and Ladage, Dennis ORCID: 0000-0002-4512-0917 (2022). Longitudinal monitoring of SARS-CoV-2 spike protein-specific antibody responses in Lower Austria. PLoS One, 17 (7). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

The Lower Austrian Wachau region was an early COVID-19 hotspot of infection. As previously reported, in June 2020, after the first peak of infections, we determined that 8.5% and 9.0% of the participants in Wei ss enkirchen and surrounding communities in the Wachau region were positive for immunoglobulin G (IgG) and immunoglobulin A (IgA) antibodies against the receptor-binding domain of the spike protein of SARS-CoV-2, respectively. Here, we present novel data obtained eight months later (February 2021) from Wei ss enkirchen, after the second peak of infection, with 25.0% (138/552) and 23.6% (130/552) of participants that are positive for IgG and IgA, respectively. In participants with previous IgG/IgA positivity (June 2020), we observed a 24% reduction in IgG levels, whereas the IgA levels remained stable in February 2021. This subgroup was further analyzed for SARS-CoV-2 induced T cell activities. Although 76% (34/45) and 76% (34/45) of IgG positive and IgA positive participants, respectively, showed specific T cell activities (upon exposure to SARS-CoV-2 spike protein-derived peptides), those were not significantly correlated with the levels of IgG or IgA. Thus, the analyses of antibodies cannot surrogate the measurement of T cell activities. For a comprehensive view on SARS-CoV-2-triggered immune responses, the measurement of different classes of antibodies should be complemented with the determination of T cell activities.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rebholz, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Braun, Ralf J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saha, Titas UNSPECIFIED UNSPECIFIED UNSPECIFIED Harzer, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Miriam UNSPECIFIED orcid.org/0000-0003-2689-8317 UNSPECIFIED Ladage, Dennis UNSPECIFIED orcid.org/0000-0002-4512-0917 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-684735
DOI:	10.1371/journal.pone.0271382
Journal or Publication Title:	PLoS One
Volume:	17
Number:	7
Date:	2022
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68473