Universität zu Köln

Wienemann, Hendrik, Meincke, Felix, Vach, Marius, Heeger, Christian-Hendrik, Meyer, Annika ORCID: 0000-0002-8411-8799, Spangenberg, Tobias, Kuck, Karl Heinz and Ghanem, Alexander . Outcome of a polymer-free drug-coated coronary stent in bifurcation lesions-Pilot registry with serial OCT imaging. Herz. MUNICH: URBAN & VOGEL. ISSN 1615-6692

Full text not available from this repository.

Abstract

Background Polymer-free and carrier-free drug-coated stents (DCS) represent a novel therapeutic option for the treatment of coronary artery disease. The objective of this pilot registry is to evaluate the safety and efficacy of DCS implantation in bifurcation lesions. Methods Overall, 23 consecutive patients with 24 lesions received a Biolimus A9-coated DCS for coronary bifurcation lesions. Patients were examined with quantitative coronary angiography (QCA) and optical coherence tomography (OCT) at 3-6 months of follow-up. Results A total of 23 patients with 24 bifurcation lesions were included in this study. Nine (33.3%) lesions of eight patients revealed angiographical target lesion failure due to in-stent restenosis (ISR). In total, 19 patients with 20 bifurcation lesions were suitable for OCT analysis. A total of 2936 struts were analyzed and 14 struts (0.47%) were classified as malapposed. The mean luminal area (mm(2)) was not different in lesions with ISR vs. lesions with no ISR (5.07 +/- 2.0 vs. 5.73 +/- 1.34, p = 0.39) at follow-up. Lesions with ISR showed higher mean neointimal burden (27.11 +/- 10.59 vs. 13.93 +/- 9.16%, respectively; p = 0.009). All of the patients who presented with significant ISR required percutaneous re-intervention. Conclusions We observed a high rate of DCS ISR in bifurcation lesions, possibly related to increased inflammation and neoatherosclerosis. The small size of the study warrants careful interpretation of our results. Larger trials are necessary to expand knowledge of these findings.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wienemann, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Meincke, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Vach, Marius UNSPECIFIED UNSPECIFIED UNSPECIFIED Heeger, Christian-Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Annika UNSPECIFIED orcid.org/0000-0002-8411-8799 UNSPECIFIED Spangenberg, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuck, Karl Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghanem, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-684853
DOI:	10.1007/s00059-022-05109-7
Journal or Publication Title:	Herz
Publisher:	URBAN & VOGEL
Place of Publication:	MUNICH
ISSN:	1615-6692
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; SIROLIMUS-ELUTING STENT; CLINICAL-APPLICATIONS; CONSENSUS DOCUMENT; RANDOMIZED-TRIAL; BARE-METAL; FOLLOW-UP; INTERVENTION; RESTENOSIS; COVERAGE Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68485