Universität zu Köln

Lazaridi, Marina, Panagiotaropoulou, Georgia ORCID: 0000-0001-9516-6158, Covanis, Panagiotis, Karantinos, Thomas, Aggelopoulos, Elias, Klein, Christoph and Smyrnis, Nikolaos (2022). Brain-Heart Link in Schizophrenia: Cognitive Inhibitory Control Deficit in Patients Is Specifically Related to Parasympathetic Dysregulation. Schizophr. Bull., 48 (5). S. 1155 - 1164. OXFORD: OXFORD UNIV PRESS. ISSN 1745-1701

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Abstract

Background This study examined the connection between two prominent deficits in schizophrenia: the deficit in parasympathetic regulation and the deficit in cognitive inhibitory control, within the framework of the Neurovisceral Integration Model (NIM). Study Design Thirty healthy controls and 30 patients with schizophrenia performed the internationally standardized antisaccade protocol while their electrocardiographic data were recorded. The interaction between the group, the cognitive inhibitory control as measured with error rate (ER) in the antisaccade task and parasympathetic activity as measured with the High Frequency power component of Heart Rate Variability (HF-HRV) was tested. Study Results Findings confirmed that decreased HF-HRV was specifically related to increased ER in patients with schizophrenia. In contrast, patient deficits in other oculomotor function measures such as reaction time and reaction time variability related to volitional movement control and cognitive stability respectively were not linked to the deficit in parasympathetic regulation. Conclusions Our study validates the theory behind NIM proposing that cognitive inhibition has common physiological substrate with parasympathetic regulation. Future research could test this brain-heart link in other mental disorders especially those with a prominent deficit in inhibitory cognitive function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lazaridi, Marina UNSPECIFIED UNSPECIFIED UNSPECIFIED Panagiotaropoulou, Georgia UNSPECIFIED orcid.org/0000-0001-9516-6158 UNSPECIFIED Covanis, Panagiotis UNSPECIFIED UNSPECIFIED UNSPECIFIED Karantinos, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Aggelopoulos, Elias UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Smyrnis, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-684959
DOI:	10.1093/schbul/sbac033
Journal or Publication Title:	Schizophr. Bull.
Volume:	48
Number:	5
Page Range:	S. 1155 - 1164
Date:	2022
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1745-1701
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RATE-VARIABILITY; NEUROVISCERAL INTEGRATION; VAGAL ACTIVITY; PREFRONTAL CORTEX; SMOOTH-PURSUIT; EYE-MOVEMENTS; NEURAL BASIS; PSYCHOPATHOLOGY; METAANALYSIS; PERFORMANCE Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68495