Universität zu Köln

Sommerer, Claudia, Schroter, Iris, Gruneberg, Katrin, Schindler, Daniela, Behnisch, Rouven, Morath, Christian, Renders, Lutz, Heemann, Uwe, Schnitzler, Paul, Melk, Anette, Della Penna, Andrea, Nadalin, Silvio, Heeg, Klaus, Meuer, Stefan, Zeier, Martin and Giese, Thomas (2022). Incidences of Infectious Events in a Renal Transplant Cohort of the German Center of Infectious Diseases (DZIF). Open Forum Infect. Dis., 9 (7). CARY: OXFORD UNIV PRESS INC. ISSN 2328-8957

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Abstract

Background Infectious complications are a major cause of morbidity and mortality after kidney transplantation. Methods In this transplant cohort study at the German Center of Infectious Diseases (DZIF), we evaluated all infections occurring during the first year after renal transplantation. We assessed microbial etiology, incidence rates, and temporal occurrence of these infections. Results Of 804 renal transplant recipients (65.2% male, 51 +/- 14 years), 439 (54.6%) had 972 infections within the first year after transplantation. Almost half of these infections (47.8%) occurred within the first 3 months. Bacteria were responsible for 66.4% (645/972) of all infections, followed by viral (28.9% [281/972]) and fungal (4.7% [46/972]) pathogens. The urinary tract was the most common site of infection (42.4%). Enterococcus was the most frequently isolated bacterium (20.9%), followed by E. coli (17.6%) and Klebsiella (12.5%). E. coli was the leading pathogen in recipients <50 years of age, whereas Enterococcus predominated in older recipients. Resistant bacteria were responsible for at least 1 infection in 9.5% (76/804) of all recipients. Viral infections occurred in 201 recipients (25.0%). Of these, herpes viruses predominated (140/281 [49.8%]), and cytomegalovirus had the highest incidence rate (12.3%). In the 46 fungal infections, Candida albicans (40.8%) was the most commonly isolated. Other fungal opportunistic pathogens, including Aspergillus fumigatus and Pneumocystis, were rare. Conclusions Renal allograft recipients in Germany experience a high burden of infectious complications in the first year after transplantation. Bacteria were the predominating pathogen, followed by opportunistic infections such as cytomegalovirus. Microbial etiology varied between age groups, and resistant bacteria were identified in 10% of recipients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sommerer, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroter, Iris UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruneberg, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schindler, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Behnisch, Rouven UNSPECIFIED UNSPECIFIED UNSPECIFIED Morath, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Renders, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Heemann, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnitzler, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Melk, Anette UNSPECIFIED UNSPECIFIED UNSPECIFIED Della Penna, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Nadalin, Silvio UNSPECIFIED UNSPECIFIED UNSPECIFIED Heeg, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Meuer, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeier, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Giese, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-685061
DOI:	10.1093/ofid/ofac243
Journal or Publication Title:	Open Forum Infect. Dis.
Volume:	9
Number:	7
Date:	2022
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	2328-8957
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ORGAN-TRANSPLANTATION; FUNGAL-INFECTIONS; RISK-FACTORS; RECIPIENTS; CYTOMEGALOVIRUS; SURVEILLANCE; REPLICATION; PREVENTION; REJECTION; ERA Multiple languages Immunology; Infectious Diseases; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68506