Juarez-Cedillo, Teresa, Martinez-Rodriguez, Nancy, Vargas-Alarcon, Gilberto, Juarez-Cedillo, Enrique, Valle-Medina, Antonio, Garrido-Acosta, Osvaldo and Ramirez, Alfredo ORCID: 0000-0003-4991-763X (2022). Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysis. Front. Aging Neurosci., 14. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-4365

Full text not available from this repository.

Abstract

ObjectiveEvidence supports the important role of neuroinflammation in some types of dementia. This study aimed to evaluate the effect of epistasis of gene cytokines such as interleukin (IL)-alpha, IL-6, tumor necrosis factor (TNF alpha), and interferon-gamma (IFN-gamma) on the susceptibility to the development of dementia. Materials and methodsIn the study, 221 patients diagnosed with dementia and 710 controls were included. The multifactor-dimensionality reduction (MDR) analysis was performed to identify the epistasis between SNP located in genes of IL-alpha (rs1800587), IL-6 (rs1800796), TNF alpha (rs361525 and rs1800629), and IFN gamma (rs2069705). The best risk prediction model was identified based on precision and cross-validation consistency. ResultsMultifactor-dimensionality reduction analysis detected a significant model with the genes TNF alpha, IFN gamma, IL1 alpha, and IL6 (prediction success: 72%, p < 0.0001). When risk factors were analyzed with these polymorphisms, the model achieved a similar prediction for dementia as the genes-only model. ConclusionThese data indicate that gene-gene interactions form significant models to identify populations susceptible to dementia.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Juarez-Cedillo, TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez-Rodriguez, NancyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vargas-Alarcon, GilbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juarez-Cedillo, EnriqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valle-Medina, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garrido-Acosta, OsvaldoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
URN: urn:nbn:de:hbz:38-685088
DOI: 10.3389/fnagi.2022.952173
Journal or Publication Title: Front. Aging Neurosci.
Volume: 14
Date: 2022
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1663-4365
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ONSET ALZHEIMERS-DISEASE; DEPENDENT ASSOCIATION; TAU-PROTEIN; INTERLEUKIN-6; EXPRESSION; METAANALYSIS; STRATEGIES; DIAGNOSIS; PATHOLOGY; BLOODMultiple languages
Geriatrics & Gerontology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/68508

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item