Universität zu Köln

Goldhardt, Oliver, Freiberger, Robert, Dreyer, Tobias, Willner, Luisa, Yakushev, Igor, Ortner, Marion, Foerstl, Hans, Diehl-Schmid, Janine, Milz, Esther, Priller, Josef, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Magdolen, Viktor, Thaler, Markus and Grimmer, Timo . Herpes simplex virus alters Alzheimer's disease biomarkers - A hypothesis paper. Alzheimers. Dement.. HOBOKEN: WILEY. ISSN 1552-5279

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Abstract

Introduction: Human herpes simplex virus 1 (HSV1) is discussed to induce amyloid-beta (A beta) accumulation and neurofibrillary tangles of hyperphosphorylated tau (pTau) in Alzheimer's disease (AD) in cell culture and animal models. A beta appears to be virostatic. We investigated the association between intrathecal antibodies against HSV or cytomegalovirus (CMV) and cerebrospinal fluid (CSF) AD biomarkers. Methods: beta(42)/A beta(40) ratio, pTau, and tTau were measured in CSF of 117 patients with early AD positive for amyloid pathology (A+) and 30 healthy controls (A-). CSF-to-serum anti-HSV1/2-IgG antibody indices (AI-IgG(HSV1/2)) and CMV (AI-IgG(CMV)) were determined by enzyme-linked immunosorbent assay (ELISA). Results: Exclusively in HSV1-seropositive AD, pTau was positively and significantly predicted by AI-IgG(HSV1/2) and negatively by the A beta(42)/A beta(40) ratio in both univariate and multivariate regression analyses. Furthermore, a significant and negative interaction between the AI-IgG(HSV1/2) and A beta(42)/A beta(40) ratio on pTau was found.Discussion: The results support the hypothesis that HSV infection contributes to AD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goldhardt, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Freiberger, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreyer, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Willner, Luisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Yakushev, Igor UNSPECIFIED UNSPECIFIED UNSPECIFIED Ortner, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerstl, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Diehl-Schmid, Janine UNSPECIFIED UNSPECIFIED UNSPECIFIED Milz, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Priller, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED Magdolen, Viktor UNSPECIFIED UNSPECIFIED UNSPECIFIED Thaler, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimmer, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-685262
DOI:	10.1002/alz.12834
Journal or Publication Title:	Alzheimers. Dement.
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1552-5279
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; TYPE-1 DNA; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; APOLIPOPROTEIN-E; BRAIN; INFECTION; TAU; PROTEINS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68526