Universität zu Köln

Sheng, Can, Yang, Kun, He, Beiqi, Li, Taoran, Wang, Xiaoqi, Du, Wenying, Hu, Xiaochen ORCID: 0000-0003-4126-673X, Jiang, Jiehui, Jiang, Xueyan, Jessen, Frank and Han, Ying (2022). Cross-Cultural Longitudinal Study on Cognitive Decline (CLoCODE) for Subjective Cognitive Decline in China and Germany: A Protocol for Study Design. J. Alzheimers Dis., 87 (3). S. 1319 - 1334. AMSTERDAM: IOS PRESS. ISSN 1875-8908

Full text not available from this repository.

Abstract

Background: Subjective cognitive decline (SCD) is considered as the first symptomatic manifestation of Alzheimer's disease (AD), which is also affected by different cultural backgrounds. Establishing cross-cultural prediction models of SCD is challenging. Objective: To establish prediction models of SCD available for both the Chinese and European populations. Methods: In this project, 330 SCD from China and 380 SCD from Germany are intended to be recruited. For all participants, standardized assessments, including clinical, neuropsychological, apolipoprotein E (APOE) genotype, blood, and multi-parameter magnetic resonance imaging (MRI) at baseline will be conducted. Participants will voluntarily undergo amyloid positron emission tomography (PET) and are classified into amyloid-beta (A beta) positive SCD (SCD+) and A beta negative SCD (SCD-). First, baseline data of all SCD individuals between the two cohorts will be compared. Then, key features associated with brain amyloidosis will be extracted in SCD+ individuals, and the diagnosis model will be established using the radiomics method. Finally, the follow-up visits will be conducted every 12 months and the primary outcome is the conversion to mild cognitive impairment or dementia. After a 4-year follow-up, we will extract factors associated with the conversion risk of SCD using Cox regression analysis. Results: At present, 141 SCD from China and 338 SCD from Germany have been recruited. Initial analysis showed significant differences in demographic information, neuropsychological tests, and regional brain atrophy in SCD compared with controls in both cohorts. Conclusion: This project may be of great value for future implications of SCD studies in different cultural backgrounds.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sheng, Can UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Kun UNSPECIFIED UNSPECIFIED UNSPECIFIED He, Beiqi UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Taoran UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Xiaoqi UNSPECIFIED UNSPECIFIED UNSPECIFIED Du, Wenying UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Xiaochen UNSPECIFIED orcid.org/0000-0003-4126-673X UNSPECIFIED Jiang, Jiehui UNSPECIFIED UNSPECIFIED UNSPECIFIED Jiang, Xueyan UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Ying UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-686141
DOI:	10.3233/JAD-215452
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	87
Number:	3
Page Range:	S. 1319 - 1334
Date:	2022
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALZHEIMERS ASSOCIATION WORKGROUPS; PLASMA AMYLOID-BETA; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; OLDER-ADULTS; DISEASE; MEMORY; IDENTIFICATION; INDIVIDUALS; IMPAIRMENT Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68614