Universität zu Köln

Gruell, Henning, Vanshylla, Kanika ORCID: 0000-0003-4552-9170, Korenkov, Michael, Tober-Lau, Pinkus, Zehner, Matthias, Munn, Friederike, Janicki, Hanna, Augustin, Max, Schommers, Philipp, Sander, Leif Erik, Kurth, Florian ORCID: 0000-0002-3807-473X, Kreer, Christoph and Klein, Florian ORCID: 0000-0003-1376-1792 (2022). SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns. Cell Host Microbe, 30 (9). S. 1231 - 1249. CAMBRIDGE: CELL PRESS. ISSN 1934-6069

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Abstract

SARS-CoV-2 neutralizing antibodies play a critical role in COVID-19 prevention and treatment but are challenged by viral evolution and the emergence of novel escape variants. Importantly, the recently identified Omicron sublineages BA.2.12.1 and BA.4/5 are rapidly becoming predominant in various countries. By deter-mining polyclonal serum activity of 50 convalescent or vaccinated individuals against BA.1, BA.1.1, BA.2, BA.2.12.1, and BA.4/5, we reveal a further reduction in BA.4/5 susceptibility to vaccinee sera. Most notably, delineation of sensitivity to an extended 163-antibody panel demonstrates pronounced antigenic differences with distinct escape patterns among Omicron sublineages. Antigenic distance and/or higher resistance may therefore favor immune-escape-mediated BA.4/5 expansion after the first Omicron wave. Finally, while most clinical-stage monoclonal antibodies are inactive against Omicron sublineages, we identify promising antibodies with high pan-SARS-CoV-2 neutralizing potency. Our study provides a detailed understanding of Omicron-sublineage antibody escape that can inform on effective strategies against COVID-19.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gruell, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Vanshylla, Kanika UNSPECIFIED orcid.org/0000-0003-4552-9170 UNSPECIFIED Korenkov, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Tober-Lau, Pinkus UNSPECIFIED UNSPECIFIED UNSPECIFIED Zehner, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Munn, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Janicki, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Augustin, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Schommers, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Sander, Leif Erik UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurth, Florian UNSPECIFIED orcid.org/0000-0002-3807-473X UNSPECIFIED Kreer, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED orcid.org/0000-0003-1376-1792 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-686162
DOI:	10.1016/j.chom.2022.07.002
Journal or Publication Title:	Cell Host Microbe
Volume:	30
Number:	9
Page Range:	S. 1231 - 1249
Date:	2022
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1934-6069
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RECEPTOR-BINDING DOMAIN; NEUTRALIZING ANTIBODIES; INFECTION Multiple languages Microbiology; Parasitology; Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68616