Wang, Xueqing, Jiang, Quanlong, Song, Yuanyuan, He, Zhidong, Zhang, Hongdao, Song, Mengjiao, Zhang, Xiaona ORCID: 0000-0001-6479-3562, Dai, Yumin, Karalay, Oezlem, Dieterich, Christoph, Antebi, Adam, Wu, Ligang, Han, Jing-Dong J. and Shen, Yidong (2022). Ageing induces tissue-specific transcriptomic changes in Caenorhabditis elegans. Embo J., 41 (8). HOBOKEN: WILEY. ISSN 1460-2075

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Abstract

Ageing is a complex process with common and distinct features across tissues. Unveiling the underlying processes driving ageing in individual tissues is indispensable to decipher the mechanisms of organismal longevity. Caenorhabditis elegans is a well-established model organism that has spearheaded ageing research with the discovery of numerous genetic pathways controlling its lifespan. However, it remains challenging to dissect the ageing of worm tissues due to the limited description of tissue pathology and access to tissue-specific molecular changes during ageing. In this study, we isolated cells from five major tissues in young and old worms and profiled the age-induced transcriptomic changes within these tissues. We observed a striking diversity of ageing across tissues and identified different sets of longevity regulators therein. In addition, we found novel tissue-specific factors, including irx-1 and myrf-2, which control the integrity of the intestinal barrier and sarcomere structure during ageing respectively. This study demonstrates the complexity of ageing across worm tissues and highlights the power of tissue-specific transcriptomic profiling during ageing, which can serve as a resource to the field.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wang, XueqingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jiang, QuanlongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Song, YuanyuanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
He, ZhidongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, HongdaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Song, MengjiaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, XiaonaUNSPECIFIEDorcid.org/0000-0001-6479-3562UNSPECIFIED
Dai, YuminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karalay, OezlemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dieterich, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antebi, AdamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wu, LigangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Han, Jing-Dong J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shen, YidongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-687041
DOI: 10.15252/embj.2021109633
Journal or Publication Title: Embo J.
Volume: 41
Number: 8
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1460-2075
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LIFE-SPAN; MUTANTS; LONG; SIGNALS; DAF-16; METABOLISM; LONGEVITY; GENETICS; RECEPTOR; TARGETSMultiple languages
Biochemistry & Molecular Biology; Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/68704

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