Universität zu Köln

Li, Changhong, Hu, Quanling, Zhang, Delong, Hoffstaedter, Felix, Bauer, Andreas and Elmenhorst, David ORCID: 0000-0001-6137-416X (2022). Neural correlates of affective control regions induced by common therapeutic strategies in major depressive disorders: An activation likelihood estimation meta-analysis study. Neurosci. Biobehav. Rev., 137. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-7528

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Abstract

In major depressive disorder (MDD), not only the pathophysiology of this disease is unknown but also the mechanisms of clinical efficacy across its therapeutic strategies are unclear. Although neuroimaging studies adopted activation likelihood estimation (ALE) approach to identify the convergent abnormalities of human brain in the MDD patients, the common alterations after antidepressant therapies were not summarized. Thus, we extracted the coordinates of brain regions in the MDD patients that showed differences in resting-state function, gray matter morphometry, and task-evoked neuronal responses after therapies. The ALE algorithm (GingerALE2.0.3) was employed in all 53 studies (64 experiments with 1406 MDD patients). Consistent results across treatment therapies were reported in the affective control network, including the bilateral thalamus, bilateral amygdala/parahippocampal gyrus, right anterior cingulate cortex/middle frontal gyrus, and right insular cortex/ claustrum. Only electroconvulsive therapy partially replicated above findings. Our results indicate the antidepressant therapies efficiently influence core structures of the affective control network, which might be the underlying mechanism of remission in depression and provides potential targets for further treatment strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Li, Changhong UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Quanling UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Delong UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffstaedter, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Elmenhorst, David UNSPECIFIED orcid.org/0000-0001-6137-416X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-687157
DOI:	10.1016/j.neubiorev.2022.104643
Journal or Publication Title:	Neurosci. Biobehav. Rev.
Volume:	137
Date:	2022
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-7528
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GRAY-MATTER VOLUME; FUNCTIONAL CONNECTIVITY; ELECTROCONVULSIVE-THERAPY; ANTIDEPRESSANT TREATMENT; TREATMENT RESPONSE; PREFRONTAL CORTEX; BRAIN; AMYGDALA; STATE; EMOTION Multiple languages Behavioral Sciences; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68715