Universität zu Köln

Xiong, Yu, Song, Jianping, Huang, Xinyue, Pan, Zhigang, Goldbrunner, Roland, Stavrinou, Lampis, Lin, Shu, Hu, Weipeng, Zheng, Feng and Stavrinou, Pantelis (2022). Exosomes Derived From Mesenchymal Stem Cells: Novel Effects in the Treatment of Ischemic Stroke. Front. Neurosci., 16. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-453X

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Abstract

Ischemic stroke is defined as an infarction in the brain, caused by impaired cerebral blood supply, leading to local brain tissue ischemia, hypoxic necrosis, and corresponding neurological deficits. At present, revascularization strategies in patients with acute ischemic stroke include intravenous thrombolysis and mechanical endovascular treatment. However, due to the short treatment time window (<4.5 h) and method restrictions, clinical research is focused on new methods to treat ischemic stroke. Exosomes are nano-sized biovesicles produced in the endosomal compartment of most eukaryotic cells, containing DNA, complex RNA, and protein (30-150 nm). They are released into surrounding extracellular fluid upon fusion between multivesicular bodies and the plasma membrane. Exosomes have the characteristics of low immunogenicity, good innate stability, high transmission efficiency, and the ability to cross the blood-brain barrier, making them potential therapeutic modalities for the treatment of ischemic stroke. The seed sequence of miRNA secreted by exosomes is base-paired with complementary mRNA to improve the microenvironment of ischemic tissue, thereby regulating downstream signal transduction activities. With exosome research still in the theoretical and experimental stages, this review aims to shed light on the potential of exosomes derived from mesenchymal stem cells in the treatment of ischemic stroke.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Xiong, Yu UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Jianping UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, Xinyue UNSPECIFIED UNSPECIFIED UNSPECIFIED Pan, Zhigang UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Stavrinou, Lampis UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Shu UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Weipeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Zheng, Feng UNSPECIFIED UNSPECIFIED UNSPECIFIED Stavrinou, Pantelis UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-687321
DOI:	10.3389/fnins.2022.899887
Journal or Publication Title:	Front. Neurosci.
Volume:	16
Date:	2022
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-453X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTRACELLULAR VESICLES; THERAPEUTIC TARGET; SIGNALING PATHWAY; STROMAL CELLS; NEUROINFLAMMATION; INJURY; REPAIR; BRAIN; NEUROGENESIS; ANGIOGENESIS Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68732