Universität zu Köln

Kramer, Isabelle Marie ORCID: 0000-0002-5106-2012, Pfenninger, Markus ORCID: 0000-0002-1547-7245, Feldmeyer, Barbara, Dhimal, Meghnath ORCID: 0000-0001-7176-7821, Gautam, Ishan, Shreshta, Pramod, Baral, Sunita, Phuyal, Parbati, Hartke, Juliane, Magdeburg, Axel, Groneberg, David A., Ahrens, Bodo ORCID: 0000-0002-6452-3180, Muller, Ruth and Waldvogel, Ann-Marie (2023). Genomic profiling of climate adaptation in Aedes aegypti along an altitudinal gradient in Nepal indicates nongradual expansion of the disease vector. Mol. Ecol., 32 (2). S. 350 - 369. HOBOKEN: WILEY. ISSN 1365-294X

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Abstract

Driven by globalization, urbanization and climate change, the distribution range of invasive vector species has expanded to previously colder ecoregions. To reduce health-threatening impacts on humans, insect vectors are extensively studied. Population genomics can reveal the genomic basis of adaptation and help to identify emerging trends of vector expansion. By applying whole genome analyses and genotype-environment associations to populations of the main dengue vector Aedes aegypti, sampled along an altitudinal gradient in Nepal (200-1300 m), we identify putatively adaptive traits and describe the species' genomic footprint of climate adaptation to colder ecoregions. We found two differentiated clusters with significantly different allele frequencies in genes associated to climate adaptation between the highland population (1300 m) and all other lowland populations (<= 800 m). We revealed nonsynonymous mutations in 13 of the candidate genes associated to either altitude, precipitation or cold tolerance and identified an isolation-by-environment differentiation pattern. Other than the expected gradual differentiation along the altitudinal gradient, our results reveal a distinct genomic differentiation of the highland population. Local high-altitude adaptation could be one explanation of the population's phenotypic cold tolerance. Carrying alleles relevant for survival under colder climate increases the likelihood of this highland population to a worldwide expansion into other colder ecoregions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kramer, Isabelle Marie UNSPECIFIED orcid.org/0000-0002-5106-2012 UNSPECIFIED Pfenninger, Markus UNSPECIFIED orcid.org/0000-0002-1547-7245 UNSPECIFIED Feldmeyer, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Dhimal, Meghnath UNSPECIFIED orcid.org/0000-0001-7176-7821 UNSPECIFIED Gautam, Ishan UNSPECIFIED UNSPECIFIED UNSPECIFIED Shreshta, Pramod UNSPECIFIED UNSPECIFIED UNSPECIFIED Baral, Sunita UNSPECIFIED UNSPECIFIED UNSPECIFIED Phuyal, Parbati UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartke, Juliane UNSPECIFIED UNSPECIFIED UNSPECIFIED Magdeburg, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Groneberg, David A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahrens, Bodo UNSPECIFIED orcid.org/0000-0002-6452-3180 UNSPECIFIED Muller, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Waldvogel, Ann-Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-687490
DOI:	10.1111/mec.16752
Journal or Publication Title:	Mol. Ecol.
Volume:	32
Number:	2
Page Range:	S. 350 - 369
Date:	2023
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-294X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOCAL ADAPTATION; DROSOPHILA-MELANOGASTER; WIDE PATTERNS; DIFFERENTIATION; DENGUE; IDENTIFICATION; URBANIZATION; ASSOCIATION; TEMPERATURE; POPULATIONS Multiple languages Biochemistry & Molecular Biology; Ecology; Evolutionary Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68749