Universität zu Köln

Tomlinson, Eve ORCID: 0000-0002-0969-602X, Pardo, Jordi Pardo, Dodd, Susanna, Sivesind, Torunn ORCID: 0000-0003-4805-0632, Szeto, Mindy D., Dellavalle, Robert P., Skoetz, Nicole ORCID: 0000-0003-4744-6192, Laughter, Melissa, Wells, George A. and Tugwell, Peter (2022). Substantial heterogeneity found in reporting mortality in Cochrane systematic reviews and Core Outcome Sets in COMET database. J. Clin. Epidemiol., 145. S. 47 - 55. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-5921

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Abstract

Objective: To explore mortality outcome usage in Cochrane systematic reviews and Core Outcome Sets for research. Study Design and Setting: Cochrane PICO searches identified Cochrane reviews (published January 2015-March 2021) including mortality outcomes. These outcomes were categorized according to terminology used: all-cause mortality, cause-specific mortality, infant mortality, maternal mortality, survival. Mortality outcomes in Core Outcome Sets (published until 2019 on the Core Outcome Measures in Effectiveness Trials (COMET) database) were also extracted and categorized. Results: In total, 2454 mortality outcomes were reported in 49% (1978/3999) of Cochrane reviews published January 2015-March 2021: all-cause (37%), infant (23%), maternal (11%), survival (10%), cause-specific (9%). Due to reviews not specifying mortality outcome type or including studies reporting no data, 11% (273/2208) remained uncategorized. Infant mortality and maternal mortality were frequently used together in reviews reporting two mortality outcomes. In total, 226 mortality outcomes were reported in 37% (165/449) of Core Outcome Sets: all-cause (48%), survival (27%), cause specific (12%), infant (9%), maternal (4%). Mortality measurement timing varied. Conclusion: Mortality outcome usage varies in Cochrane reviews and Core Outcome Sets. This is problematic for evidence-based decision-making. Greater standardization is necessary for effective utilization of health research. (C) 2022 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tomlinson, Eve UNSPECIFIED orcid.org/0000-0002-0969-602X UNSPECIFIED Pardo, Jordi Pardo UNSPECIFIED UNSPECIFIED UNSPECIFIED Dodd, Susanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Sivesind, Torunn UNSPECIFIED orcid.org/0000-0003-4805-0632 UNSPECIFIED Szeto, Mindy D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dellavalle, Robert P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Skoetz, Nicole UNSPECIFIED orcid.org/0000-0003-4744-6192 UNSPECIFIED Laughter, Melissa UNSPECIFIED UNSPECIFIED UNSPECIFIED Wells, George A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tugwell, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-687755
DOI:	10.1016/j.jclinepi.2022.01.006
Journal or Publication Title:	J. Clin. Epidemiol.
Volume:	145
Page Range:	S. 47 - 55
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-5921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RANDOMIZED-TRIALS; IMPROVE; HARMS; TIME Multiple languages Health Care Sciences & Services; Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68775