Universität zu Köln

Clemens, Benjamin, Lefort-Besnard, Jeremy, Ritter, Christoph, Smith, Elke, Votinov, Mikhail ORCID: 0000-0001-6970-6093, Derntl, Birgit, Habel, Ute and Bzdok, Danilo . Accurate machine learning prediction of sexual orientation based on brain morphology and intrinsic functional connectivity. Cereb. Cortex. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

Background Sexual orientation in humans represents a multilevel construct that is grounded in both neurobiological and environmental factors. Objective Here, we bring to bear a machine learning approach to predict sexual orientation from gray matter volumes (GMVs) or resting-state functional connectivity (RSFC) in a cohort of 45 heterosexual and 41 homosexual participants. Methods In both brain assessments, we used penalized logistic regression models and nonparametric permutation. Results We found an average accuracy of 62% (+/- 6.72) for predicting sexual orientation based on GMV and an average predictive accuracy of 92% (+/- 9.89) using RSFC. Regions in the precentral gyrus, precuneus and the prefrontal cortex were significantly informative for distinguishing heterosexual from homosexual participants in both the GMV and RSFC settings. Conclusions These results indicate that, aside from self-reports, RSFC offers neurobiological information valuable for highly accurate prediction of sexual orientation. We demonstrate for the first time that sexual orientation is reflected in specific patterns of RSFC, which enable personalized, brain-based predictions of this highly complex human trait. While these results are preliminary, our neurobiologically based prediction framework illustrates the great value and potential of RSFC for revealing biologically meaningful and generalizable predictive patterns in the human brain.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Clemens, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Lefort-Besnard, Jeremy UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritter, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Smith, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Votinov, Mikhail UNSPECIFIED orcid.org/0000-0001-6970-6093 UNSPECIFIED Derntl, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Habel, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Bzdok, Danilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-688434
DOI:	10.1093/cercor/bhac323
Journal or Publication Title:	Cereb. Cortex
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1460-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENDER IDENTITY; PSYCHOSEXUAL DEVELOPMENT; LINKAGE; ROBUST; WOMEN; DIFFERENTIATION; HOMOSEXUALITY; OPTIMIZATION; REGISTRATION; CHROMOSOME Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68843