Universität zu Köln

Nowacki, Andreas ORCID: 0000-0001-7876-3225, Barlatey, Sabry, Al-Fatly, Bassam ORCID: 0000-0003-0067-6177, Dembek, Till, Bot, Maarten, Green, Alexander L., Kubler, Dorothee, Lachenmayer, M. Lenard, Debove, Ines, Segura-Amil, Alba ORCID: 0000-0003-1009-1826, Horn, Andreas ORCID: 0000-0002-0695-6025, Visser-Vandewalle, Veerle ORCID: 0000-0002-5274-7929, Schuurman, Rick, Barbe, Michael, Aziz, Tipu Z., Kuhn, Andrea A. ORCID: 0000-0002-4134-9060, Nguyen, T. A. Khoa ORCID: 0000-0003-0577-5035 and Pollo, Claudio (2022). Probabilistic Mapping Reveals Optimal Stimulation Site in Essential Tremor. Ann. Neurol., 91 (5). S. 602 - 613. HOBOKEN: WILEY. ISSN 1531-8249

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Abstract

Objective The objective of this study was to obtain individual clinical and neuroimaging data of patients undergoing deep brain stimulation (DBS) for essential tremor (ET) from 5 different European centers to identify predictors of outcome and to identify an optimal stimulation site. Methods We analyzed retrospectively baseline covariates, pre- and postoperative clinical tremor scores (for 12 months) as well as individual imaging data from 119 patients to obtain individual electrode positions and stimulation volumes. Individual imaging and clinical data were used to calculate a probabilistic stimulation map in normalized space using voxel-wise statistical analysis. Finally, we used this map to train a classifier to predict tremor improvement. Results Probabilistic mapping of stimulation effects yielded a statistically significant cluster that was associated with a tremor improvement >50%. This cluster of optimal stimulation extended from the posterior subthalamic area to the ventralis intermedius nucleus and coincided with a normative structural connectivity-based cerebellothalamic tract (CTT). The combined features distance between the stimulation volume and the significant cluster and CTT activation were used as a predictor of tremor improvement. This correctly classified a >50% tremor improvement with a sensitivity of 89% and a specificity of 57%. Interpretation Our multicenter ET probabilistic stimulation map identified an area of optimal stimulation along the course of the CTT. The results of this study are mainly descriptive until confirmed in independent datasets, ideally through prospective testing. This target will be made openly available and may be used to guide surgical planning and for computer-assisted programming of DBS in the future. ANN NEUROL 2022

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nowacki, Andreas UNSPECIFIED orcid.org/0000-0001-7876-3225 UNSPECIFIED Barlatey, Sabry UNSPECIFIED UNSPECIFIED UNSPECIFIED Al-Fatly, Bassam UNSPECIFIED orcid.org/0000-0003-0067-6177 UNSPECIFIED Dembek, Till UNSPECIFIED UNSPECIFIED UNSPECIFIED Bot, Maarten UNSPECIFIED UNSPECIFIED UNSPECIFIED Green, Alexander L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kubler, Dorothee UNSPECIFIED UNSPECIFIED UNSPECIFIED Lachenmayer, M. Lenard UNSPECIFIED UNSPECIFIED UNSPECIFIED Debove, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Segura-Amil, Alba UNSPECIFIED orcid.org/0000-0003-1009-1826 UNSPECIFIED Horn, Andreas UNSPECIFIED orcid.org/0000-0002-0695-6025 UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED orcid.org/0000-0002-5274-7929 UNSPECIFIED Schuurman, Rick UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Aziz, Tipu Z. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Andrea A. UNSPECIFIED orcid.org/0000-0002-4134-9060 UNSPECIFIED Nguyen, T. A. Khoa UNSPECIFIED orcid.org/0000-0003-0577-5035 UNSPECIFIED Pollo, Claudio UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-689130
DOI:	10.1002/ana.26324
Journal or Publication Title:	Ann. Neurol.
Volume:	91
Number:	5
Page Range:	S. 602 - 613
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8249
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; MOTOR CORTEX; ZONA INCERTA; PROJECTIONS; CEREBELLAR; NUCLEUS; ORGANIZATION; TRANSPORT; PARKINSON; AREA Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68913