Universität zu Köln

Mulla, Yuval, Avellaneda, Mario J., Roland, Antoine, Baldauf, Lucia ORCID: 0000-0001-5200-4044, Jung, Wonyeong, Kim, Taeyoon, Tans, Sander J. and Koenderink, Gijsje H. (2022). Weak catch bonds make strong networks. Nat. Mater., 21 (9). S. 1019 - 1037. BERLIN: NATURE PORTFOLIO. ISSN 1476-4660

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Abstract

Molecular catch bonds are ubiquitous in biology and essential for processes like leucocyte extravasion(1) and cellular mechanosensing(2). Unlike normal (slip) bonds, catch bonds strengthen under tension. The current paradigm is that this feature provides 'strength on demand(3)', thus enabling cells to increase rigidity under stress(1)(,4-6). However, catch bonds are often weaker than slip bonds because they have cryptic binding sites that are usually buried(7)(,8). Here we show that catch bonds render reconstituted cytoskeletal actin networks stronger than slip bonds, even though the individual bonds are weaker. Simulations show that slip bonds remain trapped in stress-free areas, whereas weak binding allows catch bonds to mitigate crack initiation by moving to high-tension areas. This 'dissociation on demand' explains how cells combine mechanical strength with the adaptability required for shape change, and is relevant to diseases where catch bonding is compromised(7)(,9), including focal segmental glomerulosclerosis(10) caused by the alpha-actinin-4 mutant studied here. We surmise that catch bonds are the key to create life-like materials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mulla, Yuval UNSPECIFIED UNSPECIFIED UNSPECIFIED Avellaneda, Mario J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roland, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldauf, Lucia UNSPECIFIED orcid.org/0000-0001-5200-4044 UNSPECIFIED Jung, Wonyeong UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Taeyoon UNSPECIFIED UNSPECIFIED UNSPECIFIED Tans, Sander J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenderink, Gijsje H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-689821
DOI:	10.1038/s41563-022-01288-0
Journal or Publication Title:	Nat. Mater.
Volume:	21
Number:	9
Page Range:	S. 1019 - 1037
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	1476-4660
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADHESION; MECHANISMS; GENERATION; DYNAMICS; CELLS; FORMS Multiple languages Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68982