Universität zu Köln

Sarfo, Fred Stephen, Dompreh, Albert, Asibey, Shadrack Osei, Boateng, Richard, Weinreich, Felix, Kuffour, Edmund Osei, Norman, Betty ORCID: 0000-0002-4075-5972, Di Cristanziano, Veronica, Frickmann, Hagen, Feldt, Torsten and Eberhardt, Kirsten Alexandra (2022). The Clinical Features and Immunological Signature of Cyclospora cayetanensis Co-Infection among People Living with HIV in Ghana. Microorganisms, 10 (7). BASEL: MDPI. ISSN 2076-2607

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Abstract

Background: There is a paucity of information on the contemporary burden, disease patterns, and immunological profile of people living with HIV who are co-infected with C. cayetanensis in the post-antiretroviral therapy era. Methods: For this cross-sectional study, stool samples of 640 HIV-positive and 83 HIV-negative individuals in Ghana were tested for C. cayetanensis. Additionally, sociodemographic parameters, clinical symptoms, medical drug intake, and immunological parameters were assessed. Results: The prevalence of C. cayetanensis was 8.75% (n = 56) in HIV-positive and 1.20% (n = 1) in HIV-negative participants (p = 0.015). Within the group of HIV-positive participants, the prevalence reached 13.6% in patients with CD4+ T cell counts below 200 cells/mu l. Frequencies of the clinical manifestations of weight loss and diarrheal disease were significantly higher in patients with C. cayetanensis compared to those without co-infection (36.36% vs. 22.59%, p = 0.034 and 20.00% vs. 4.90%, p < 0.001, respectively). The expression of markers of immune activation and exhaustion of T lymphocyte sub-populations was significantly elevated in patients colonized with C. cayetanensis. Conclusions: In the modern post-combined antiretroviral therapy (cART) era, the acquisition of C. cayetanensis among PLWH in Ghana is driven largely by the immunosuppression profile characterized by high expression of markers of immune activation and immune exhaustion.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sarfo, Fred Stephen UNSPECIFIED UNSPECIFIED UNSPECIFIED Dompreh, Albert UNSPECIFIED UNSPECIFIED UNSPECIFIED Asibey, Shadrack Osei UNSPECIFIED UNSPECIFIED UNSPECIFIED Boateng, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Weinreich, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuffour, Edmund Osei UNSPECIFIED UNSPECIFIED UNSPECIFIED Norman, Betty UNSPECIFIED orcid.org/0000-0002-4075-5972 UNSPECIFIED Di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED Frickmann, Hagen UNSPECIFIED UNSPECIFIED UNSPECIFIED Feldt, Torsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Eberhardt, Kirsten Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-690378
DOI:	10.3390/microorganisms10071407
Journal or Publication Title:	Microorganisms
Volume:	10
Number:	7
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-2607
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTESTINAL PARASITES; INFECTED PATIENTS; PREVALENCE; TRANSMISSION; TRAVELERS; DIARRHEA; ADULTS Multiple languages Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69037