Universität zu Köln

Jimeno, Natalia ORCID: 0000-0002-9618-3424, Gomez-Pilar, Javier, Poza, Jesus ORCID: 0000-0001-8577-9559, Hornero, Roberto, Vogeley, Kai ORCID: 0000-0002-5891-5831, Meisenzahl, Eva, Lichtenstein, Theresa K., Rosen, Marlene, Kambeitz, Joseph, Klosterkoetter, Joachim and Schultze-Lutter, Frauke (2022). (Attenuated) hallucinations join basic symptoms in a transdiagnostic network cluster analysis. Schizophr. Res., 243. S. 43 - 55. AMSTERDAM: ELSEVIER. ISSN 1573-2509

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Abstract

Hallucinations are considered characteristic symptoms of psychosis and part of the 'psychosis superspectrum' of the Hierarchical Taxonomy Of Psychopathology (HiTOP) initiative. To gain insight into their psychopathological relevance, we studied their dimensional placement within a single dense transdiagnostic network constituting of basic symptoms as well as of attenuated and frank psychotic, and related symptoms. Newman's modularity analysis was used to detect symptom clusters in an earlier generated network (Jimeno, N., et al., 2020. Main symptomatic treatment targets in suspected and early psychosis: New insights from network analysis. Schizophr. Bull. 46, 884-895. https://doi.org/10.1093/schbul/sbz140). The constituting 86 symptoms were assessed with the Schizophrenia Proneness Instrument, Adult version (SPI-A), the Structured Interview for Psychosis-Risk Syndromes (SIPS), and the Positive And Negative Syndrome Scale (PANSS) in three adult samples of an early detection service: clinical high-risk (n = 203), first-episode psychosis (n = 153), and major depression (n = 104). Three clusters were detected: subjective disturbances , positive symptoms and behaviors , and negative and anxious-depressive symptoms . The predominately attenuated hallucinations of both SIPS and PANSS joined the basic symptoms in subjective disturbances , whereas other positive symptoms entered positive symptoms and behaviors . Our results underline the importance of insight in separating true psychotic hallucinations from other hallucinatory experiences that, albeit phenomenologically similar are still experienced with some insight, i.e., are present in an attenuated form. We conclude that, strictly, hallucinations held with any degree of insight should not be used to diagnose transition to or presence of frank psychoses and, relatedly, to justify antipsychotic medication.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jimeno, Natalia UNSPECIFIED orcid.org/0000-0002-9618-3424 UNSPECIFIED Gomez-Pilar, Javier UNSPECIFIED UNSPECIFIED UNSPECIFIED Poza, Jesus UNSPECIFIED orcid.org/0000-0001-8577-9559 UNSPECIFIED Hornero, Roberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogeley, Kai UNSPECIFIED orcid.org/0000-0002-5891-5831 UNSPECIFIED Meisenzahl, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Lichtenstein, Theresa K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosen, Marlene UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz, Joseph UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultze-Lutter, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-690499
DOI:	10.1016/j.schres.2022.02.018
Journal or Publication Title:	Schizophr. Res.
Volume:	243
Page Range:	S. 43 - 55
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1573-2509
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEGATIVE-SYNDROME-SCALE; ULTRA-HIGH-RISK; HIERARCHICAL TAXONOMY; PSYCHOSIS SYMPTOMS; 5-FACTOR MODEL; SCHIZOPHRENIA; CRITERIA; PSYCHOPATHOLOGY; PREVALENCE; ADOLESCENTS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69049