Universität zu Köln

Trempler, Ima, Binder, Ellen, Reuter, Martin, Plieger, Thomas, Standke, Isabel, Mecklenbrauck, Falko ORCID: 0000-0002-8187-6826, Meinert, Susanne ORCID: 0000-0003-2177-7161, Forstner, Andreas J., Nothen, Markus M., Rietschel, Marcella ORCID: 0000-0002-5236-6149, Sturmer, Sophie, Dannlowski, Udo, Tittgemeyer, Marc, Lencer, Rebekka, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Schubotz, Ricarda, I (2022). Effects of DRD2/ANKK1 and COMT Val158Met polymorphisms on stabilization against and adaptation to unexpected events. Cereb. Cortex, 32 (24). S. 5698 - 5716. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

Full text not available from this repository.

Abstract

Genetic variations affecting dopaminergic neuromodulation such as the DRD2/ANKK1 and the COMT Val158Met polymorphisms contribute to goal-directed behavior that requires a balance between stabilization and updating of current states and behaviors. Dopamine is also thought to be relevant for encoding of surprise signals to sensory input and adaptive learning. A link between goal-directed behavior and learning from surprise is therefore plausible. In the present fMRI study, we investigated whether DRD2 and COMT polymorphisms are related to behavioral responses and neural signals in the caudate nucleus and dlPFC during updating or stabilizing internal models of predictable digit sequences. To-be-detected switches between sequences and to-be-ignored digit omissions within a sequence varied by information-theoretic quantities of surprise and entropy. We found that A1 noncarriers and Val-carriers showed a lower response threshold along with increased caudate and dlPFC activation to surprising switches compared with A1-carriers and Met-homozygotes, whose dlPFC activity increased with decreasing switch surprise. In contrast, there were overall smaller differences in behavioral and neural modulation by drift surprise. Our results suggest that the impact of dopamine-relevant polymorphisms in the flexibility-stability trade-off may result in part from the role of dopamine in encoding the weight afforded to events requiring updating or stabilization.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Trempler, Ima UNSPECIFIED UNSPECIFIED UNSPECIFIED Binder, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuter, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Plieger, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Standke, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED Mecklenbrauck, Falko UNSPECIFIED orcid.org/0000-0002-8187-6826 UNSPECIFIED Meinert, Susanne UNSPECIFIED orcid.org/0000-0003-2177-7161 UNSPECIFIED Forstner, Andreas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nothen, Markus M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rietschel, Marcella UNSPECIFIED orcid.org/0000-0002-5236-6149 UNSPECIFIED Sturmer, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Dannlowski, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Lencer, Rebekka UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Schubotz, Ricarda, I UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-690995
DOI:	10.1093/cercor/bhac046
Journal or Publication Title:	Cereb. Cortex
Volume:	32
Number:	24
Page Range:	S. 5698 - 5716
Date:	2022
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1460-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CATECHOL-O-METHYLTRANSFERASE; DOPAMINE-RECEPTOR GENE; WORKING-MEMORY; BASAL GANGLIA; VAL(158)MET GENOTYPE; POSTERIOR CONNECTIVITY; MOLECULAR-GENETICS; DRD2 POLYMORPHISM; COGNITIVE CONTROL; VAL(108/158) MET Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69099