Universität zu Köln

Dobbertin-Welsch, Josefine ORCID: 0000-0003-4260-5879, Staudacher, Olga, Yuerek, Songuel, Trendelenburg, Valerie, Tschirner, Sebastian, Ziegert, Mandy, Ahrens, Frank, Millner-Uhlemann, Martina, Buesing, Susanne, Striegel, Anne, Ott, Hagen, Arens, Alisa, Gappa, Monica, Lange, Lars, Gernert, Sunhild, Niggemann, Bodo and Beyer, Kirsten (2022). Organ-specific symptom patterns during oral food challenge in children with peanut and tree nut allergy. Pediatr. Allergy Immunol., 33 (5). HOBOKEN: WILEY. ISSN 1399-3038

Full text not available from this repository.

Abstract

Background Peanut and tree nut allergies are common in childhood and often severe in nature. The clinical picture shows a wide variety of symptoms. Objective To analyze the distribution of clinical symptoms and severity during oral food challenges (OFC) in children. Methods Analysis of 1.013 prospectively recorded, positive OFCs with peanut (n = 607), hazelnut (n = 266), walnut (n = 97), and cashew (n = 43). Symptoms were categorized as immediate-type skin, gastrointestinal, upper and lower respiratory, cardiovascular symptoms, and eczema exacerbation. Symptom severity and treatment were recorded. Results Skin symptoms presented in 78%, followed by gastrointestinal (47%), upper (42%), and lower respiratory symptoms (32%). Cardiovascular symptoms presented in 6%. In three-quarter of the reactions, more than one organ was involved. Importantly, severe reactions occurred at every dose level. Peanut- and cashew-allergic patients had a higher relative risk of gastrointestinal symptoms compared with hazelnut- and walnut-allergic patients. Patients without vomiting had a 1.7 times higher risk developing immediate-type skin and/or lower respiratory symptoms. Three-quarter of the patients ever had eczema but worsening presented in only 10.5% of the OFCs. In patients with multiple food allergies, organs involved, eliciting dose and severity differed between allergens. Conclusion Although comparisons between allergen groups with different clinical history, severity, comorbidities and laboratory data are difficult and might contain bias, our data confirm the high allergenic potential of peanut and tree nuts. The rare occurrence of eczema worsening emphasizes that avoidance diets of peanuts and tree nuts to cure eczema seem to be unnecessary and may hamper tolerance maintenance.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dobbertin-Welsch, Josefine UNSPECIFIED orcid.org/0000-0003-4260-5879 UNSPECIFIED Staudacher, Olga UNSPECIFIED UNSPECIFIED UNSPECIFIED Yuerek, Songuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Trendelenburg, Valerie UNSPECIFIED UNSPECIFIED UNSPECIFIED Tschirner, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziegert, Mandy UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahrens, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Millner-Uhlemann, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Buesing, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Striegel, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, Hagen UNSPECIFIED UNSPECIFIED UNSPECIFIED Arens, Alisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Gappa, Monica UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Gernert, Sunhild UNSPECIFIED UNSPECIFIED UNSPECIFIED Niggemann, Bodo UNSPECIFIED UNSPECIFIED UNSPECIFIED Beyer, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-691040
DOI:	10.1111/pai.13778
Journal or Publication Title:	Pediatr. Allergy Immunol.
Volume:	33
Number:	5
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1399-3038
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMMUNOGLOBULIN-E LEVELS; NATURAL-HISTORY; DOUBLE-BLIND; SENSITIZATION; ANAPHYLAXIS; POPULATION; REACTIVITY; RISK; LIFE Multiple languages Allergy; Immunology; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69104