Universität zu Köln

Randerath, Winfried ORCID: 0000-0002-5010-8461, de Lange, Jan, Hedner, Jan, Ho, Jean Pierre T. F., Marklund, Marie, Schiza, Sofia, Steier, Jorg and Verbraecken, Johan (2022). Current and novel treatment options for obstructive sleep apnoea. ERJ Open Res., 8 (2). SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. ISSN 2312-0541

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Abstract

Obstructive sleep apnoea is a challenging medical problem due to its prevalence, its impact on quality of life and performance in school and professionally, the implications for risk of accidents, and comorbidities and mortality. Current research has carved out a broad spectrum of clinical phenotypes and defined major pathophysiological components. These findings point to the concept of personalised therapy, oriented on both the distinct clinical presentation and the most relevant pathophysiology in the individual patient. This leads to questions of whether sufficient therapeutic options other than positive airway pressure (PAP) alone are available, for which patients they may be useful, if there are specific indications for single or combined treatment, and whether there is solid scientific evidence for recommendations. This review describes our knowledge on PAP and non-PAP therapies to address upper airway collapsibility, muscle responsiveness, arousability and respiratory drive. The spectrum is broad and heterogeneous, including technical and pharmaceutical options already in clinical use or at an advanced experimental stage. Although there is an obvious need for more research on single or combined therapies, the available data demonstrate the variety of effective options, which should replace the unidirectional focus on PAP therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Randerath, Winfried UNSPECIFIED orcid.org/0000-0002-5010-8461 UNSPECIFIED de Lange, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hedner, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ho, Jean Pierre T. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marklund, Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiza, Sofia UNSPECIFIED UNSPECIFIED UNSPECIFIED Steier, Jorg UNSPECIFIED UNSPECIFIED UNSPECIFIED Verbraecken, Johan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-691051
DOI:	10.1183/23120541.00126-2022
Journal or Publication Title:	ERJ Open Res.
Volume:	8
Number:	2
Date:	2022
Publisher:	EUROPEAN RESPIRATORY SOC JOURNALS LTD
Place of Publication:	SHEFFIELD
ISSN:	2312-0541
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITIVE AIRWAY PRESSURE; TRANSCUTANEOUS ELECTRICAL-STIMULATION; MANDIBULAR ADVANCEMENT DEVICE; RAPID MAXILLARY EXPANSION; RESPIRATORY DISTURBANCE INDEX; LONG-TERM EFFECTIVENESS; TENNIS BALL TECHNIQUE; MAXILLOMANDIBULAR ADVANCEMENT; DOUBLE-BLIND; WEIGHT-LOSS Multiple languages Respiratory System Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69105