Universität zu Köln

Horemheb-Rubio, Gibran, Eggeling, Ralf, Schmeisser, Norbert, Pfeifer, Nico ORCID: 0000-0002-4647-8566, Lengauer, Thomas, Gaertner, Barbara C., Prifert, Christiane, Kochanek, Matthias, Scheid, Christoph, Adams, Ortwin and Kaiser, Rolf ORCID: 0000-0002-2640-2548 (2022). Respiratory viruses dynamics and interactions: ten years of surveillance in central Europe. BMC Public Health, 22 (1). LONDON: BMC. ISSN 1471-2458

Full text not available from this repository.

Abstract

Background Lower respiratory tract infections are among the main causes of death. Although there are many respiratory viruses, diagnostic efforts are focused mainly on influenza. The Respiratory Viruses Network (RespVir) collects infection data, primarily from German university hospitals, for a high diversity of infections by respiratory pathogens. In this study, we computationally analysed a subset of the RespVir database, covering 217,150 samples tested for 17 different viral pathogens in the time span from 2010 to 2019. Methods We calculated the prevalence of 17 respiratory viruses, analysed their seasonality patterns using information-theoretic measures and agglomerative clustering, and analysed their propensity for dual infection using a new metric dubbed average coinfection exclusion score (ACES). Results After initial data pre-processing, we retained 206,814 samples, corresponding to 1,408,657 performed tests. We found that Influenza viruses were reported for almost the half of all infections and that they exhibited the highest degree of seasonality. Coinfections of viruses are frequent; the most prevalent coinfection was rhinovirus/bocavirus and most of the virus pairs had a positive ACES indicating a tendency to exclude each other regarding infection. Conclusions The analysis of respiratory viruses dynamics in monoinfection and coinfection contributes to the prevention, diagnostic, treatment, and development of new therapeutics. Data obtained from multiplex testing is fundamental for this analysis and should be prioritized over single pathogen testing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Horemheb-Rubio, Gibran UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggeling, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmeisser, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeifer, Nico UNSPECIFIED orcid.org/0000-0002-4647-8566 UNSPECIFIED Lengauer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaertner, Barbara C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Prifert, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Kochanek, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Adams, Ortwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED orcid.org/0000-0002-2640-2548 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-691457
DOI:	10.1186/s12889-022-13555-5
Journal or Publication Title:	BMC Public Health
Volume:	22
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1471-2458
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VIRAL-INFECTIONS; INFLUENZA; CHILDREN Multiple languages Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69145