Universität zu Köln

Xu, David ORCID: 0000-0003-3649-4746, Garg, Elisha, Lee, Kook, Sakurada, Yoichi, Amphornphruet, Atchara, Phasukkijwatana, Nopasak, Liakopoulos, Sandra, Pautler, Scott Eugene, Kreiger, Allan E., Yzer, Suzanne, Lee, Won Ki, Sadda, SriniVas, Freund, K. Bailey ORCID: 0000-0002-7888-9773 and Sarraf, David (2022). Long-term visual and anatomic outcomes of patients with peripapillary pachychoroid syndrome. Br. J. Ophthalmol., 106 (4). S. 576 - 582. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2079

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Abstract

Background/Aims To analyse the long-term anatomic and visual outcomes of patients with peripapillary pachychoroid syndrome (PPS), a recently described entity in the pachychoroid disease spectrum. Methods This study retrospectively included patients from several retina centres worldwide. Visual acuity (VA), retinal thickness and choroidal thickness at baseline, 6 months and final follow-up were assessed. Temporal trends in VA and anatomic characteristics were evaluated. Visual and anatomic outcomes in eyes that were observed versus those that were treated were analysed. Results Fifty-six eyes of 35 patients were included with mean follow-up of 27 +/- 17 months. Median VA was 20/36 at baseline and remained stable through follow-up (p=0.77). Retinal thickness significantly decreased subfoveally (p=0.012), 1.5 mm nasal to the fovea (p=0.002) and 3.0 mm nasal to the fovea (p=0.0035) corresponding to areas of increased thickening at baseline. Choroidal thickness significantly decreased subfoveally (p=0.0030) and 1.5 mm nasal to the fovea (p=0.0030). Forty-three eyes were treated with modalities including antivascular endothelial growth factor injection, photodynamic therapy, and others. VA remained stable in treated eyes over follow-up (p=0.67). An isolated peripapillary fluid pocket in the outer nuclear layer was characteristic of PPS. Conclusion Patients with PPS experienced decreased retinal oedema and decreased choroidal thickening throughout the course of disease. While some patients experienced visual decline, the overall visual outcome was relatively favourable and independent of trends in retinal or choroidal thickening.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Xu, David UNSPECIFIED orcid.org/0000-0003-3649-4746 UNSPECIFIED Garg, Elisha UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Kook UNSPECIFIED UNSPECIFIED UNSPECIFIED Sakurada, Yoichi UNSPECIFIED UNSPECIFIED UNSPECIFIED Amphornphruet, Atchara UNSPECIFIED UNSPECIFIED UNSPECIFIED Phasukkijwatana, Nopasak UNSPECIFIED UNSPECIFIED UNSPECIFIED Liakopoulos, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Pautler, Scott Eugene UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreiger, Allan E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yzer, Suzanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Won Ki UNSPECIFIED UNSPECIFIED UNSPECIFIED Sadda, SriniVas UNSPECIFIED UNSPECIFIED UNSPECIFIED Freund, K. Bailey UNSPECIFIED orcid.org/0000-0002-7888-9773 UNSPECIFIED Sarraf, David UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-691528
DOI:	10.1136/bjophthalmol-2019-315550
Journal or Publication Title:	Br. J. Ophthalmol.
Volume:	106
Number:	4
Page Range:	S. 576 - 582
Date:	2022
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-2079
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CENTRAL SEROUS CHORIORETINOPATHY; CHOROIDAL THICKNESS CHANGES; INTRAVITREAL BEVACIZUMAB; ASSOCIATION; EFFICACY Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69152