Universität zu Köln

van der Weele, Linda ORCID: 0000-0001-8713-4260, Pollastro, Sabrina, van Schaik, Barbera D. C., van Kampen, Antoine H. C., Niewold, Ilse T. G., Kuijpers, Taco W., Warnke, Clemens ORCID: 0000-0002-3510-9255, Jensen, Poul Erik H., Kramer, Daniel, Ryner, Malin, Hermanrud, Christina, Donnes, Pierre, Pallardy, Marc, Spindeldreher, Sebastian, Deisenhammer, Florian, Fogdell-Hahn, Anna and de Vries, Niek (2022). Longitudinal analysis of anti-drug antibody development in multiple sclerosis patients treated with interferon beta-1a (Rebif (TM)) using B cell receptor repertoire analysis. J. Neuroimmunol., 370. AMSTERDAM: ELSEVIER. ISSN 1872-8421

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Abstract

A significant proportion of multiple sclerosis (MS) patients treated with interferon beta-1a (Rebif (TM)) develop anti-drug antibodies (ADA) with a negative impact on treatment efficacy. We hypothesized that high-throughput B-cell receptor (BCR) repertoire analysis could be used to predict and monitor ADA development. To study this we analyzed 228 peripheral blood samples from 68 longitudinally followed patients starting on interferon beta-1a. Our results show that whole blood BCR analysis does not reflect, and does not predict ADA development in MS patients treated with interferon beta-1a. We propose that BCR analysis of phenotypically selected cell subsets or tissues might be more informative.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van der Weele, Linda UNSPECIFIED orcid.org/0000-0001-8713-4260 UNSPECIFIED Pollastro, Sabrina UNSPECIFIED UNSPECIFIED UNSPECIFIED van Schaik, Barbera D. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Kampen, Antoine H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Niewold, Ilse T. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuijpers, Taco W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnke, Clemens UNSPECIFIED orcid.org/0000-0002-3510-9255 UNSPECIFIED Jensen, Poul Erik H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kramer, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Ryner, Malin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermanrud, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Donnes, Pierre UNSPECIFIED UNSPECIFIED UNSPECIFIED Pallardy, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Spindeldreher, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Deisenhammer, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Fogdell-Hahn, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED de Vries, Niek UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-691735
DOI:	10.1016/j.jneuroim.2022.577932
Journal or Publication Title:	J. Neuroimmunol.
Volume:	370
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1872-8421
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUTRALIZING ANTIBODIES; IFN-BETA; RELEVANCE Multiple languages Immunology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69173