Universität zu Köln

Petrosino, Giuseppe, Ponte, Giovanna, Volpe, Massimiliano ORCID: 0000-0003-4184-5264, Zarrella, Ilaria, Ansaloni, Federico ORCID: 0000-0002-6344-4931, Langella, Concetta, Di Cristina, Giulia, Finaurini, Sara, Russo, Monia T., Basu, Swaraj ORCID: 0000-0001-6107-2487, Musacchia, Francesco, Ristoratore, Filomena, Pavlinic, Dinko, Benes, Vladimir, Ferrante, Maria I., Albertin, Caroline, Simakov, Oleg, Gustincich, Stefano, Fiorito, Graziano and Sanges, Remo (2022). Identification of LINE retrotransposons and long non-coding RNAs expressed in the octopus brain. BMC Biol., 20 (1). LONDON: BMC. ISSN 1741-7007

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Abstract

Background Transposable elements (TEs) widely contribute to the evolution of genomes allowing genomic innovations, generating germinal and somatic heterogeneity, and giving birth to long non-coding RNAs (lncRNAs). These features have been associated to the evolution, functioning, and complexity of the nervous system at such a level that somatic retrotransposition of long interspersed element (LINE) L1 has been proposed to be associated to human cognition. Among invertebrates, octopuses are fascinating animals whose nervous system reaches a high level of complexity achieving sophisticated cognitive abilities. The sequencing of the genome of the Octopus bimaculoides revealed a striking expansion of TEs which were proposed to have contributed to the evolution of its complex nervous system. We recently found a similar expansion also in the genome of Octopus vulgaris. However, a specific search for the existence and the transcription of full-length transpositionally competent TEs has not been performed in this genus. Results Here, we report the identification of LINE elements competent for retrotransposition in Octopus vulgaris and Octopus bimaculoides and show evidence suggesting that they might be transcribed and determine germline and somatic polymorphisms especially in the brain. Transcription and translation measured for one of these elements resulted in specific signals in neurons belonging to areas associated with behavioral plasticity. We also report the transcription of thousands of lncRNAs and the pervasive inclusion of TE fragments in the transcriptomes of both Octopus species, further testifying the crucial activity of TEs in the evolution of the octopus genomes. Conclusions The neural transcriptome of the octopus shows the transcription of thousands of putative lncRNAs and of a full-length LINE element belonging to the RTE class. We speculate that a convergent evolutionary process involving retrotransposons activity in the brain has been important for the evolution of sophisticated cognitive abilities in this genus.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Petrosino, Giuseppe UNSPECIFIED UNSPECIFIED UNSPECIFIED Ponte, Giovanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Volpe, Massimiliano UNSPECIFIED orcid.org/0000-0003-4184-5264 UNSPECIFIED Zarrella, Ilaria UNSPECIFIED UNSPECIFIED UNSPECIFIED Ansaloni, Federico UNSPECIFIED orcid.org/0000-0002-6344-4931 UNSPECIFIED Langella, Concetta UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Cristina, Giulia UNSPECIFIED UNSPECIFIED UNSPECIFIED Finaurini, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Russo, Monia T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Basu, Swaraj UNSPECIFIED orcid.org/0000-0001-6107-2487 UNSPECIFIED Musacchia, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Ristoratore, Filomena UNSPECIFIED UNSPECIFIED UNSPECIFIED Pavlinic, Dinko UNSPECIFIED UNSPECIFIED UNSPECIFIED Benes, Vladimir UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferrante, Maria I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Albertin, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Simakov, Oleg UNSPECIFIED UNSPECIFIED UNSPECIFIED Gustincich, Stefano UNSPECIFIED UNSPECIFIED UNSPECIFIED Fiorito, Graziano UNSPECIFIED UNSPECIFIED UNSPECIFIED Sanges, Remo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-692066
DOI:	10.1186/s12915-022-01303-5
Journal or Publication Title:	BMC Biol.
Volume:	20
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1741-7007
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LEARNING-SYSTEM; VERTICAL LOBE; R PACKAGE; ANNOTATION; GENOME; TOOL; ORIGIN; GENES; CELLS; CEPHALOPODS Multiple languages Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69206