Universität zu Köln

Boss, Michael A., Snyder, Bradley S., Kim, Eunhee, Flamini, Dena, Englander, Sarah, Sundaram, Karthik M., Gumpeni, Naveen, Palmer, Suzanne L., Choi, Haesun ORCID: 0000-0002-3565-5475, Froemming, Adam T., Persigehl, Thorsten, Davenport, Matthew S., Malyarenko, Dariya, Chenevert, Thomas L. and Rosen, Mark A. (2022). Repeatability and Reproducibility Assessment of the Apparent Diffusion Coefficient in the Prostate: A Trial of the ECOG-ACRIN Research Group (ACRIN 6701). J. Magn. Reson. Imaging, 56 (3). S. 668 - 680. HOBOKEN: WILEY. ISSN 1522-2586

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Abstract

Background Uncertainty regarding the reproducibility of the apparent diffusion coefficient (ADC) hampers the use of quantitative diffusion-weighted imaging (DWI) in evaluation of the prostate with magnetic resonance imaging MRI. The quantitative imaging biomarkers alliance (QIBA) profile for quantitative DWI claims a within-subject coefficient of variation (wCV) for prostate lesion ADC of 0.17. Improved understanding of ADC reproducibility would aid the use of quantitative diffusion in prostate MRI evaluation. Purpose Evaluation of the repeatability (same-day) and reproducibility (multi-day) of whole-prostate and focal-lesion ADC assessment in a multi-site setting. Study Type Prospective multi-institutional. Subjects Twenty-nine males, ages 53 to 80 (median 63) years, following diagnosis of prostate cancer, 10 with focal lesions. Field Strength/Sequence 3T, single-shot spin-echo diffusion-weighted echo-planar sequence with four b-values. Assessment Sites qualified for the study using an ice-water phantom with known ADC. Readers performed DWI analyses at visit 1 (V1) and visit 2 (V2, 2-14 days after V1), where V2 comprised scans before (V2pre) and after (V2post) a coffee-break interval with subject removal and repositioning. A single reader segmented the whole prostate. Two readers separately placed region-of-interests for focal lesions. Statistical Tests Reproducibility and repeatability coefficients for whole prostate and focal lesions derived from median pixel ADC. We estimated the wCV and 95% confidence interval using a variance stabilizing transformation and assessed interreader reliability of focal lesion ADC using the intraclass correlation coefficient (ICC). Results The ADC biases from b(0)-b(600) and b(0)-b(800) phantom scans averaged 1.32% and 1.44%, respectively; mean b-value dependence was 0.188%. Repeatability and reproducibility of whole prostate median pixel ADC both yielded wCVs of 0.033 (N = 29). In 10 subjects with an evaluable focal lesion, the individual reader wCVs were 0.148 and 0.074 (repeatability) and 0.137 and 0.078 (reproducibility). All time points demonstrated good to excellent interreader reliability for focal lesion ADC (ICCV1 = 0.89; ICCV2pre = 0.76; ICCV2post = 0.94). Data Conclusion This study met the QIBA claim for prostate ADC. Test-retest repeatability and multi-day reproducibility were largely equivalent. Interreader reliability for focal lesion ADC was high across time points. Level of Evidence 1 Technical Efficacy Stage 2 TOC Category Pelvis

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Boss, Michael A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Snyder, Bradley S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Eunhee UNSPECIFIED UNSPECIFIED UNSPECIFIED Flamini, Dena UNSPECIFIED UNSPECIFIED UNSPECIFIED Englander, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Sundaram, Karthik M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gumpeni, Naveen UNSPECIFIED UNSPECIFIED UNSPECIFIED Palmer, Suzanne L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Choi, Haesun UNSPECIFIED orcid.org/0000-0002-3565-5475 UNSPECIFIED Froemming, Adam T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Persigehl, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Davenport, Matthew S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Malyarenko, Dariya UNSPECIFIED UNSPECIFIED UNSPECIFIED Chenevert, Thomas L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosen, Mark A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-692206
DOI:	10.1002/jmri.28093
Journal or Publication Title:	J. Magn. Reson. Imaging
Volume:	56
Number:	3
Page Range:	S. 668 - 680
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1522-2586
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUANTITATIVE IMAGING BIOMARKERS; WEIGHTED MRI; VALUES; WATER Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69220