Universität zu Köln

Roche, Johanna, Rasmussen, Peter, Gatterer, Hannes ORCID: 0000-0002-5084-2930, Roveri, Giulia, Turner, Rachel, van Hall, Gerrit ORCID: 0000-0002-2519-8127, Maillard, Marc, Walzl, Anna, Kob, Michael, Strapazzon, Giacomo ORCID: 0000-0002-4402-8633, Goetze, Jens Peter ORCID: 0000-0001-6356-3829, Schaefer, Simon Thomas, Kammerer, Tobias ORCID: 0000-0001-8920-7187, Nader, Elie ORCID: 0000-0002-6054-2456, Connes, Philippe, Robert, Melanie, Mueller, Thomas, Feraille, Eric and Siebenmann, Christoph (2022). Hypoxia briefly increases diuresis but reduces plasma volume by fluid redistribution in women. Am. J. Physiol.-Heart Circul. Physiol., 323 (6). S. H1068 - 12. Rockville: AMER PHYSIOLOGICAL SOC. ISSN 1522-1539

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Abstract

We have recently reported that hypobaric hypoxia (HH) reduces plasma volume (PV) in men by decreasing total circulating plasma protein (TCPP). Here, we investigated whether this applies to women and whether an inflammatory response and/or endothelial glycocalyx shedding could facilitate the TCCP reduction. We further investigated whether acute HH induces a short-lived diuretic response that was overlooked in our recent study, where only 24-h urine volumes were evaluated. In a strictly controlled crossover protocol, 12 women underwent two 4-day sojourns in a hypobaric chamber: one in normoxia (NX) and one in HH equivalent to 3,500-m altitude. PV, urine output, TCPP, and markers for inflammation and glycocalyx shedding were repeatedly measured. Total body water (TBW) was determined pre- and postsojourns by deuterium dilution. PV was reduced after 12 h of HH and thereafter remained 230-330 mL lower than in NX (P < 0.0001). Urine flow was 45% higher in HH than in NX throughout the first 6 h (P = 0.01) but lower during the second half of the first day (P < 0.001). Twenty-four-hour urine volumes (P > 0.37) and TBW (P > 0.14) were not different between the sojourns. TCPP was lower in HH than in NX at the same time points as PV (P < 0.001), but inflammatory or glycocalyx shedding markers were not consistently increased. As in men, and despite initially increased diuresis, HH-induced PV contraction in women is driven by a loss of TCPP and ensuing fluid redistribution, rather than by fluid loss. The mechanism underlying the TCPP reduction remains unclear but does not seem to involve inflammation or glycocalyx shedding. NEW & NOTEWORTHY This study is the first to investigate the mechanisms underlying plasma volume (PV) contraction in response to hypoxia in women while strictly controlling for confounders. PV contraction in women has a similar time course and magnitude as in men and is driven by the same mechanism, namely, oncotically driven redistribution rather than loss of fluid. We further report that hypoxia facilitates an increase in diuresis, that is, however, short-lived and of little relevance for PV regulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roche, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Rasmussen, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Gatterer, Hannes UNSPECIFIED orcid.org/0000-0002-5084-2930 UNSPECIFIED Roveri, Giulia UNSPECIFIED UNSPECIFIED UNSPECIFIED Turner, Rachel UNSPECIFIED UNSPECIFIED UNSPECIFIED van Hall, Gerrit UNSPECIFIED orcid.org/0000-0002-2519-8127 UNSPECIFIED Maillard, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Walzl, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Kob, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Strapazzon, Giacomo UNSPECIFIED orcid.org/0000-0002-4402-8633 UNSPECIFIED Goetze, Jens Peter UNSPECIFIED orcid.org/0000-0001-6356-3829 UNSPECIFIED Schaefer, Simon Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kammerer, Tobias UNSPECIFIED orcid.org/0000-0001-8920-7187 UNSPECIFIED Nader, Elie UNSPECIFIED orcid.org/0000-0002-6054-2456 UNSPECIFIED Connes, Philippe UNSPECIFIED UNSPECIFIED UNSPECIFIED Robert, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Feraille, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebenmann, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-692236
DOI:	10.1152/ajpheart.00394.2022
Journal or Publication Title:	Am. J. Physiol.-Heart Circul. Physiol.
Volume:	323
Number:	6
Page Range:	S. H1068 - 12
Date:	2022
Publisher:	AMER PHYSIOLOGICAL SOC
Place of Publication:	Rockville
ISSN:	1522-1539
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE MOUNTAIN-SICKNESS; HIGH-ALTITUDE; NATRIURETIC PEPTIDE; EXERCISE; ALBUMIN; ASCENT; WATER; VASOCONSTRICTION; INTERLEUKIN-6; PERMEABILITY Multiple languages Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69223