Universität zu Köln

Merkle-Storms, Julia, Djordjevic, Ilija ORCID: 0000-0002-5810-8626, Sabashnikov, Anton, Eghbalzadeh, Kaveh, Gkouziouta, Aggeliki, Fiane, Arnt, Stockman, Bernard, Montalto, Andrea ORCID: 0000-0003-3802-3147, Bernhardt, Alexander, Meyns, Bart, Netuka, Ivan, De By, Theo, Wahlers, Thorsten, Rahmanian, Parwis and Zeriouh, Mohamed (2022). Comparative analysis of LVAD patients in regard of ischaemic or idiopathic cardiomyopathy: A propensity-score analysis of EUROMACS data. Int. J. Artif. Organs, 45 (3). S. 284 - 292. LONDON: SAGE PUBLICATIONS LTD. ISSN 1724-6040

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Abstract

Background: Despite recent advances in management of patients with advanced heart failure, mortality remains high. Aim of this study was to compare impact of different aetiology of ischaemic and idiopathic cardiomyopathy on early outcomes and long-term survival of patients after left ventricular assist device implantation. Methods: European Registry for Patients with Mechanical Circulatory Support (EUROMACS) gathers clinical data and follow-up parameters of LVAD recipients. Patients enrolled in the EUROMACS registry with primary diagnosis of either ischaemic (n = 1190) or idiopathic (n = 812) cardiomyopathy were included. Primary Endpoints were early mortality as well as long-term survival. Secondary endpoint were major postoperative adverse events, such as need for rethoracotomy. Additionally, a propensity-score matching analysis was performed for patients with ischaemic (n = 509) and idiopathic (n = 509) cardiomyopathy. Results: In terms of basic demographics and baseline parameters the two groups significantly differed as expected before propensity-score matching due to different aetiology of cardiomyopathy. Seven-day (52 (4.4%) versus 18 (2.2%); p = 0.009), 30-day (153 (12.9%) versus 73 (9.0%); p = 0.008) and in-hospital mortality (253 (19.7%) versus 123 (15.1%); p = 0.009) were significantly lower in the idiopathic cardiomyopathy group compared to the ischaemic cardiomyopathy group, whereas after propensity-score matching 30-day (p = 0.169) was comparable and in-hospital mortality (p = 0.051) was almost significant. Kaplan-Meier survival analysis revealed no significant difference in regard of long-term survival after propensity-score matching (Breslow-test p = 0.161 and LogRank-test p = 0.113). Conclusion: Though patients with ischaemic and idiopathic cardiomyopathy suffer from different cardiomyopathy aetiologies, 30-day-mortality and long-term survival of both groups were similar leading to the conclusion that covariates predominately influence mortality and survival of ischaemic and idiopathic cardiomyopathies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Merkle-Storms, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Djordjevic, Ilija UNSPECIFIED orcid.org/0000-0002-5810-8626 UNSPECIFIED Sabashnikov, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Eghbalzadeh, Kaveh UNSPECIFIED UNSPECIFIED UNSPECIFIED Gkouziouta, Aggeliki UNSPECIFIED UNSPECIFIED UNSPECIFIED Fiane, Arnt UNSPECIFIED UNSPECIFIED UNSPECIFIED Stockman, Bernard UNSPECIFIED UNSPECIFIED UNSPECIFIED Montalto, Andrea UNSPECIFIED orcid.org/0000-0003-3802-3147 UNSPECIFIED Bernhardt, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyns, Bart UNSPECIFIED UNSPECIFIED UNSPECIFIED Netuka, Ivan UNSPECIFIED UNSPECIFIED UNSPECIFIED De By, Theo UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Rahmanian, Parwis UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeriouh, Mohamed UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-692396
DOI:	10.1177/03913988221075045
Journal or Publication Title:	Int. J. Artif. Organs
Volume:	45
Number:	3
Page Range:	S. 284 - 292
Date:	2022
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1724-6040
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENTRICULAR ASSIST DEVICES; HEART-FAILURE; CIRCULATORY SUPPORT; EUROPEAN REGISTRY; DILATED CARDIOMYOPATHY; GENDER-DIFFERENCES; EXPERIENCE; OUTCOMES Multiple languages Engineering, Biomedical; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69239