Streeck, Hendrik, Jansen, Klaus, Crowell, Trevor A. ORCID: 0000-0001-5947-265X, Esber, Allahna ORCID: 0000-0001-5337-0126, Jessen, Heiko K., Cordes, Christiane, Scholten, Stefan, Schneeweiss, Stephan, Brockmeyer, Norbert, Spinner, Christoph D., Bickel, Markus, Esser, Stefan, Hartikainen, Jukka, Stoehr, Albrecht, Lehmann, Clara, Marcus, Ulrich, Vehreschild, Joerg Janne, Knorr, Alexandra, Brillen, Anna-Lena, Tiemann, Carsten, Robb, Merlin L. and Michael, Nelson L. (2022). HIV pre-exposure prophylaxis was associated with no impact on sexually transmitted infection prevalence in a high-prevalence population of predominantly men who have sex with men, Germany, 2018 to 2019. Eurosurveillance, 27 (14). STOCKHOLM: EUR CENTRE DIS PREVENTION & CONTROL. ISSN 1560-7917

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Abstract

Introduction: Despite increased use of pre-exposure prophylaxis (PrEP) in Germany, HIV infection rates are not declining and little is known about how this prevention method affects the prevalence of sexually transmitted infections (STI) among men who have sex with men (MSM). Aim: We studied, in a large mutticentre cohort, STI point prevalence, co-infection rates, anatomical location and influence of PrEP. Methods: The BRAHMS study was a prospective cohort study conducted at io sites in seven major German cities that enrolled MSM reporting increased sexual risk behaviour. At screening visits, MSM were tested for Mycoplasma genitalium (MG), Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Treponema pallidum (TP), and given a behavioural questionnaire. With binomial regression, we estimated prevalence ratios (PR) and 95% confidence intervals (CI) for the association of PrEP and STI. Results: We screened 1,043 MSM in 2018 and 2019, with 53.0% currently using PrEP. At screening, 37o participants (35.5%) had an STI. The most common pathogen was MG in 198 (19.0%) participants, followed by CT (n =133; 12.8%), NG (n =105; 10.1%) and TP (n =37; 3.5%). Among the 370 participants with at least one STI, 14.6% (n=54) reported STI-related symptoms. Infection prevalence was highest at anorectal site (13.4% MG, 6.5% NG, 10.2% CT). PrEP use was not statistically significant in adjusted models for STI (PR: 1.10; 95% CI: 0.91-1.32), NG/CT, only NG or only CT. Conclusions: Prevalence of asymptomatic STI was high, and PrEP use did not influence STI prevalence in MSM eligible for PrEP according to national guidelines.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Streeck, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansen, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crowell, Trevor A.UNSPECIFIEDorcid.org/0000-0001-5947-265XUNSPECIFIED
Esber, AllahnaUNSPECIFIEDorcid.org/0000-0001-5337-0126UNSPECIFIED
Jessen, Heiko K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cordes, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scholten, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneeweiss, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brockmeyer, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spinner, Christoph D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bickel, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esser, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartikainen, JukkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoehr, AlbrechtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, ClaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marcus, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Joerg JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knorr, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brillen, Anna-LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tiemann, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robb, Merlin L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michael, Nelson L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-692594
DOI: 10.2807/1560-7917.ES.2022.27.14.2100591
Journal or Publication Title: Eurosurveillance
Volume: 27
Number: 14
Date: 2022
Publisher: EUR CENTRE DIS PREVENTION & CONTROL
Place of Publication: STOCKHOLM
ISSN: 1560-7917
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MYCOPLASMA-GENITALIUM; NONGONOCOCCAL URETHRITIS; CHLAMYDIA; GONORRHEAMultiple languages
Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69259

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