Universität zu Köln

Balajoo, Somayeh Maleki, Rahmani, Farzaneh, Khosrowabadi, Reza, Meng, Chun, Eickhoff, Simon B., Grimmer, Timo, Zarei, Mojtaba, Drzezga, Alexander, Sorg, Christian and Tahmasian, Masoud ORCID: 0000-0003-3999-3807 (2022). Decoupling of regional neural activity and inter-regional functional connectivity in Alzheimer's disease: a simultaneous PET/MR study. Eur. J. Nucl. Med. Mol. Imaging, 49 (9). S. 3173 - 3186. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Purpose Alzheimer's disease (AD) and mild cognitive impairment (MCI) are characterized by both aberrant regional neural activity and disrupted inter-regional functional connectivity (FC). However, the effect of AD/MCI on the coupling between regional neural activity (measured by regional fluorodeoxyglucose imaging (rFDG)) and inter-regional FC (measured by resting-state functional magnetic resonance imaging (rs-fMRI)) is poorly understood. Methods We scanned 19 patients with MCI, 33 patients with AD, and 26 healthy individuals by simultaneous FDG-PET/rs-fMRI and assessed rFDG and inter-regional FC metrics (i.e., clustering coefficient and degree centrality). Next, we examined the potential moderating effect of disease status (MCI or AD) on the link between rFDG and inter-regional FC metrics using hierarchical moderated multiple regression analysis. We also tested this effect by considering interaction between disease status and inter-regional FC metrics, as well as interaction between disease status and rFDG. Results Our findings revealed that both rFDG and inter-regional FC metrics were disrupted in MCI and AD. Moreover, AD altered the relationship between rFDG and inter-regional FC metrics. In particular, we found that AD moderated the effect of inter-regional FC metrics of the caudate, parahippocampal gyrus, angular gyrus, supramarginal gyrus, frontal pole, inferior temporal gyrus, middle frontal, lateral occipital, supramarginal gyrus, precuneus, and thalamus on predicting their rFDG. On the other hand, AD moderated the effect of rFDG of the parietal operculum on predicting its inter-regional FC metric. Conclusion Our findings demonstrated that AD decoupled the link between regional neural activity and functional segregation and global connectivity across particular brain regions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Balajoo, Somayeh Maleki UNSPECIFIED UNSPECIFIED UNSPECIFIED Rahmani, Farzaneh UNSPECIFIED UNSPECIFIED UNSPECIFIED Khosrowabadi, Reza UNSPECIFIED UNSPECIFIED UNSPECIFIED Meng, Chun UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimmer, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Zarei, Mojtaba UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Sorg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Tahmasian, Masoud UNSPECIFIED orcid.org/0000-0003-3999-3807 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-692611
DOI:	10.1007/s00259-022-05692-1
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	49
Number:	9
Page Range:	S. 3173 - 3186
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; RESTING-STATE NETWORKS; GREY-MATTER; TAU; BRAIN; HYPOMETABOLISM; ACCUMULATION; VARIABILITY; METABOLISM; TOPOLOGY Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69261