Universität zu Köln

Prange, Stephane ORCID: 0000-0002-0812-7634, Lin, Zhengyu ORCID: 0000-0002-9797-9272, Nourredine, Mikail ORCID: 0000-0002-0952-0091, Danaila, Teodor, Laurencin, Chloe, Lagha-Boukbiza, Ouhaid, Anheim, Mathieu, Klinger, Helene, Longato, Nadine, Phillipps, Clelie, Voirin, Jimmy, Polo, Gustavo, Simon, Emile, Mertens, Patrick, Rolland, Anne-Sophie ORCID: 0000-0001-7888-9354, Devos, David, Metereau, Elise, Tranchant, Christine and Thobois, Stephane (2022). Limbic Stimulation Drives Mania in STN-DBS in Parkinson Disease: A Prospective Study. Ann. Neurol., 92 (3). S. 411 - 418. HOBOKEN: WILEY. ISSN 1531-8249

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Abstract

In this one-year prospective study, Parkinson's disease (PD) patients with or without mania following STN-DBS were compared to investigate risk and etiological factors, clinical management and consequences. Eighteen (16.2%) out of 111 consecutive PD patients developed mania, of whom 17 were males. No preoperative risk factor was identified. Postoperative mania was related to ventral limbic subthalamic stimulation in 15 (83%) patients, and resolved as stimulation was relocated to the sensorimotor STN, besides discontinuation or reduction of dopamine agonists and use of low-dose clozapine in 12 patients, while motor and nonmotor outcomes were similar. These findings underpin the prominent role of limbic subthalamic stimulation in postoperative mania. ANN NEUROL 2022

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Prange, Stephane UNSPECIFIED orcid.org/0000-0002-0812-7634 UNSPECIFIED Lin, Zhengyu UNSPECIFIED orcid.org/0000-0002-9797-9272 UNSPECIFIED Nourredine, Mikail UNSPECIFIED orcid.org/0000-0002-0952-0091 UNSPECIFIED Danaila, Teodor UNSPECIFIED UNSPECIFIED UNSPECIFIED Laurencin, Chloe UNSPECIFIED UNSPECIFIED UNSPECIFIED Lagha-Boukbiza, Ouhaid UNSPECIFIED UNSPECIFIED UNSPECIFIED Anheim, Mathieu UNSPECIFIED UNSPECIFIED UNSPECIFIED Klinger, Helene UNSPECIFIED UNSPECIFIED UNSPECIFIED Longato, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Phillipps, Clelie UNSPECIFIED UNSPECIFIED UNSPECIFIED Voirin, Jimmy UNSPECIFIED UNSPECIFIED UNSPECIFIED Polo, Gustavo UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Emile UNSPECIFIED UNSPECIFIED UNSPECIFIED Mertens, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Rolland, Anne-Sophie UNSPECIFIED orcid.org/0000-0001-7888-9354 UNSPECIFIED Devos, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Metereau, Elise UNSPECIFIED UNSPECIFIED UNSPECIFIED Tranchant, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Thobois, Stephane UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693121
DOI:	10.1002/ana.26434
Journal or Publication Title:	Ann. Neurol.
Volume:	92
Number:	3
Page Range:	S. 411 - 418
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8249
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS STIMULATION; HYPOMANIA; MOOD; SYMPTOMS; SURGERY Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69312